tetano
Editor, Senior Moderator
Thromb Res
. 2020 Dec 11;198:135-138.
doi: 10.1016/j.thromres.2020.12.001. Online ahead of print.
Incidence of symptomatic venous thromboembolism following hospitalization for coronavirus disease 2019: Prospective results from a multi-center study
Farid Rashidi[SUP] 1 [/SUP], Stefano Barco[SUP] 2 [/SUP], Farin Kamangar[SUP] 3 [/SUP], Gustavo A Heresi[SUP] 4 [/SUP], Ashkan Emadi[SUP] 5 [/SUP], Cihangir Kaymaz[SUP] 6 [/SUP], Pavel Jansa[SUP] 7 [/SUP], Abilio Reis[SUP] 8 [/SUP], Arash Rashidi[SUP] 9 [/SUP], Ali Taghizadieh[SUP] 10 [/SUP], Parisa Rezaeifar[SUP] 10 [/SUP], Minoosh Moghimi[SUP] 11 [/SUP], Samad Ghodrati[SUP] 12 [/SUP], Abolfazl Mozafari[SUP] 13 [/SUP], Ali Alavi Foumani[SUP] 14 [/SUP], Ouria Tahamtan[SUP] 10 [/SUP], Effat Rafiee[SUP] 12 [/SUP], Zahra Abbaspour[SUP] 15 [/SUP], Kasra Khodadadi[SUP] 16 [/SUP], Golsa Alamdari[SUP] 10 [/SUP], Yasman Boodaghi[SUP] 10 [/SUP], Maryam Rezaei[SUP] 10 [/SUP], Muhammad Javad Muhammadi[SUP] 17 [/SUP], Meysam Abbasi[SUP] 17 [/SUP], Fatemeh Movaseghi[SUP] 13 [/SUP], Ata Koohi[SUP] 10 [/SUP], Leila Shakourzad[SUP] 10 [/SUP], Fatemeh Ebrahimi[SUP] 10 [/SUP], Sarvin Radvar[SUP] 10 [/SUP], Maryam Amoozadeh[SUP] 10 [/SUP], Fatemeh Fereidooni[SUP] 10 [/SUP], Hanieh Naseari[SUP] 10 [/SUP], Kobra Movalled[SUP] 10 [/SUP], Ozra Ghorbani[SUP] 10 [/SUP], Khalil Ansarin[SUP] 10 [/SUP]
Affiliations
Abstract
Background: Thrombosis and pulmonary embolism appear to be major causes of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients. However, few studies have focused on the incidence of venous thromboembolism (VTE) after hospitalization for COVID-19.
Methods: In this multi-center study, we followed 1529 COVID-19 patients for at least 45 days after hospital discharge, who underwent routine telephone follow-up. In case of signs or symptoms of pulmonary embolism (PE) or deep vein thrombosis (DVT), they were invited for an in-hospital visit with a pulmonologist. The primary outcome was symptomatic VTE within 45 days of hospital discharge.
Results: Of 1529 COVID-19 patients discharged from hospital, a total of 228 (14.9%) reported potential signs or symptoms of PE or DVT and were seen for an in-hospital visit. Of these, 13 and 12 received Doppler ultrasounds or pulmonary CT angiography, respectively, of whom only one patient was diagnosed with symptomatic PE. Of 51 (3.3%) patients who died after discharge, two deaths were attributed to VTE corresponding to a 45-day cumulative rate of symptomatic VTE of 0.2% (95%CI 0.1%-0.6%; n = 3). There was no evidence of acute respiratory distress syndrome (ARDS) in these patients. Other deaths after hospital discharge included myocardial infarction (n = 13), heart failure (n = 9), and stroke (n = 9).
Conclusions: We did not observe a high rate of symptomatic VTE in COVID-19 patients after hospital discharge. Routine extended thromboprophylaxis after hospitalization for COVID-19 may not have a net clinical benefit. Randomized trials may be warranted.
Keywords: COVID-19; Cohort study; Hospitalization; Thromboprophylaxis; Venous thromboembolism.
. 2020 Dec 11;198:135-138.
doi: 10.1016/j.thromres.2020.12.001. Online ahead of print.
Incidence of symptomatic venous thromboembolism following hospitalization for coronavirus disease 2019: Prospective results from a multi-center study
Farid Rashidi[SUP] 1 [/SUP], Stefano Barco[SUP] 2 [/SUP], Farin Kamangar[SUP] 3 [/SUP], Gustavo A Heresi[SUP] 4 [/SUP], Ashkan Emadi[SUP] 5 [/SUP], Cihangir Kaymaz[SUP] 6 [/SUP], Pavel Jansa[SUP] 7 [/SUP], Abilio Reis[SUP] 8 [/SUP], Arash Rashidi[SUP] 9 [/SUP], Ali Taghizadieh[SUP] 10 [/SUP], Parisa Rezaeifar[SUP] 10 [/SUP], Minoosh Moghimi[SUP] 11 [/SUP], Samad Ghodrati[SUP] 12 [/SUP], Abolfazl Mozafari[SUP] 13 [/SUP], Ali Alavi Foumani[SUP] 14 [/SUP], Ouria Tahamtan[SUP] 10 [/SUP], Effat Rafiee[SUP] 12 [/SUP], Zahra Abbaspour[SUP] 15 [/SUP], Kasra Khodadadi[SUP] 16 [/SUP], Golsa Alamdari[SUP] 10 [/SUP], Yasman Boodaghi[SUP] 10 [/SUP], Maryam Rezaei[SUP] 10 [/SUP], Muhammad Javad Muhammadi[SUP] 17 [/SUP], Meysam Abbasi[SUP] 17 [/SUP], Fatemeh Movaseghi[SUP] 13 [/SUP], Ata Koohi[SUP] 10 [/SUP], Leila Shakourzad[SUP] 10 [/SUP], Fatemeh Ebrahimi[SUP] 10 [/SUP], Sarvin Radvar[SUP] 10 [/SUP], Maryam Amoozadeh[SUP] 10 [/SUP], Fatemeh Fereidooni[SUP] 10 [/SUP], Hanieh Naseari[SUP] 10 [/SUP], Kobra Movalled[SUP] 10 [/SUP], Ozra Ghorbani[SUP] 10 [/SUP], Khalil Ansarin[SUP] 10 [/SUP]
Affiliations
- PMID: 33338976
- DOI: 10.1016/j.thromres.2020.12.001
Abstract
Background: Thrombosis and pulmonary embolism appear to be major causes of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients. However, few studies have focused on the incidence of venous thromboembolism (VTE) after hospitalization for COVID-19.
Methods: In this multi-center study, we followed 1529 COVID-19 patients for at least 45 days after hospital discharge, who underwent routine telephone follow-up. In case of signs or symptoms of pulmonary embolism (PE) or deep vein thrombosis (DVT), they were invited for an in-hospital visit with a pulmonologist. The primary outcome was symptomatic VTE within 45 days of hospital discharge.
Results: Of 1529 COVID-19 patients discharged from hospital, a total of 228 (14.9%) reported potential signs or symptoms of PE or DVT and were seen for an in-hospital visit. Of these, 13 and 12 received Doppler ultrasounds or pulmonary CT angiography, respectively, of whom only one patient was diagnosed with symptomatic PE. Of 51 (3.3%) patients who died after discharge, two deaths were attributed to VTE corresponding to a 45-day cumulative rate of symptomatic VTE of 0.2% (95%CI 0.1%-0.6%; n = 3). There was no evidence of acute respiratory distress syndrome (ARDS) in these patients. Other deaths after hospital discharge included myocardial infarction (n = 13), heart failure (n = 9), and stroke (n = 9).
Conclusions: We did not observe a high rate of symptomatic VTE in COVID-19 patients after hospital discharge. Routine extended thromboprophylaxis after hospitalization for COVID-19 may not have a net clinical benefit. Randomized trials may be warranted.
Keywords: COVID-19; Cohort study; Hospitalization; Thromboprophylaxis; Venous thromboembolism.