tetano
Editor, Senior Moderator
Thromb Haemost
. 2025 Apr 2.
doi: 10.1055/a-2572-1170. Online ahead of print. Behavior of Soluble C-type Lectin-Like Receptor 2 levels in Patients with Coronavirus Disease 2019-associated with Thrombosis
Hideo Wada[SUP] 1 [/SUP], Katsuya Shiraki[SUP] 1 [/SUP], Yuhuko Ichkawa[SUP] 2 [/SUP], Nobuo Ito[SUP] 3 [/SUP], Hidekazu Inoue[SUP] 4 [/SUP], Isao Moritani[SUP] 5 [/SUP], Jun Masuda[SUP] 6 [/SUP], Akitaka Yamamoto[SUP] 2 [/SUP], Masaki Tomida[SUP] 7 [/SUP], Masamichi Yoshida[SUP] 8 [/SUP], Masahide Kawamura[SUP] 9 [/SUP], Motomu Shimaoka[SUP] 10 [/SUP], Toshi Iba[SUP] 11 [/SUP], Hideto Shimpo[SUP] 2 [/SUP]
Affiliations
Background: Coronavirus disease 2019 (COVID-19) is often associated with thrombosis. Elevated levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a biomarker for platelet activation, have been reported in COVID-19. Therefore, we examined the behavior of sCLEC-2 levels and their relationship with thrombosis.
Methods: The clinical course of inflammatory and thrombotic biomarkers was assessed in 271 patients with COVID-19.
Results: Inflammatory biomarkers such as C-reactive protein, procalcitonin and presepsin levels were significantly increased in patients with COVID-19, and these behaviors differed among the clinical course or stages. The plasma D-dimer levels increased slightly and gradually. Platelet counts were within the normal range, and plasma sCLEC-2 levels were markedly increased in most patients with COVID-19. There were 17 patients with thrombosis in this study. Although there was no significant difference in various biomarkers between COVID-19 patients with and without thrombosis, the super formula of sCLEC-2xD-dimer/platelet count in patients with thrombosis was significantly higher than in those without thrombosis. Furthermore, this super formula was significantly higher in COVID-19 patients with severe or critical illness than in those with mild or moderate illness.
Conclusion: Elevation of the super formula of sCLEC-2xD-dimer/platelet count was associated with the thrombosis in patients with COVID-19 suggesting the thrombosis in COVID-19 may be caused by the development of microthrombosis.
. 2025 Apr 2.
doi: 10.1055/a-2572-1170. Online ahead of print. Behavior of Soluble C-type Lectin-Like Receptor 2 levels in Patients with Coronavirus Disease 2019-associated with Thrombosis
Hideo Wada[SUP] 1 [/SUP], Katsuya Shiraki[SUP] 1 [/SUP], Yuhuko Ichkawa[SUP] 2 [/SUP], Nobuo Ito[SUP] 3 [/SUP], Hidekazu Inoue[SUP] 4 [/SUP], Isao Moritani[SUP] 5 [/SUP], Jun Masuda[SUP] 6 [/SUP], Akitaka Yamamoto[SUP] 2 [/SUP], Masaki Tomida[SUP] 7 [/SUP], Masamichi Yoshida[SUP] 8 [/SUP], Masahide Kawamura[SUP] 9 [/SUP], Motomu Shimaoka[SUP] 10 [/SUP], Toshi Iba[SUP] 11 [/SUP], Hideto Shimpo[SUP] 2 [/SUP]
Affiliations
- PMID: 40174637
- DOI: 10.1055/a-2572-1170
Background: Coronavirus disease 2019 (COVID-19) is often associated with thrombosis. Elevated levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a biomarker for platelet activation, have been reported in COVID-19. Therefore, we examined the behavior of sCLEC-2 levels and their relationship with thrombosis.
Methods: The clinical course of inflammatory and thrombotic biomarkers was assessed in 271 patients with COVID-19.
Results: Inflammatory biomarkers such as C-reactive protein, procalcitonin and presepsin levels were significantly increased in patients with COVID-19, and these behaviors differed among the clinical course or stages. The plasma D-dimer levels increased slightly and gradually. Platelet counts were within the normal range, and plasma sCLEC-2 levels were markedly increased in most patients with COVID-19. There were 17 patients with thrombosis in this study. Although there was no significant difference in various biomarkers between COVID-19 patients with and without thrombosis, the super formula of sCLEC-2xD-dimer/platelet count in patients with thrombosis was significantly higher than in those without thrombosis. Furthermore, this super formula was significantly higher in COVID-19 patients with severe or critical illness than in those with mild or moderate illness.
Conclusion: Elevation of the super formula of sCLEC-2xD-dimer/platelet count was associated with the thrombosis in patients with COVID-19 suggesting the thrombosis in COVID-19 may be caused by the development of microthrombosis.