Pathfinder
Editor, Senior Moderator
Correspondence
Three Cases of Vertical Transmission of Clade Ib Mpox Virus
Published June 18, 2025
N Engl J Med 2025;392:2385-2387
DOI: 10.1056/NEJMc2503347
VOL. 392 NO. 23
Copyright © 2025
To the Editor:
Mpox (formerly known as monkeypox), which is caused by the virus MPXV, has been associated with adverse pregnancy outcomes, but evidence of vertical transmission remains limited.[SUP]1-3[/SUP] Concerns regarding transplacental transmission are heightened by the ongoing clade Ib mpox epidemic, which often affects persons of reproductive age.[SUP]4[/SUP] We report three cases of clade Ib MPXV infection in pregnant women in whom we assessed molecular and histopathological evidence of transplacental transmission across all trimesters. Details of the methods, clinical presentation, and histopathological testing are provided in the Supplementary Appendix, available with the full text of this letter at NEJM.org.
...
https://www.nejm.org/doi/full/10.1056/NEJMc2503347
Three Cases of Vertical Transmission of Clade Ib Mpox Virus
Published June 18, 2025
N Engl J Med 2025;392:2385-2387
DOI: 10.1056/NEJMc2503347
VOL. 392 NO. 23
Copyright © 2025
To the Editor:
Mpox (formerly known as monkeypox), which is caused by the virus MPXV, has been associated with adverse pregnancy outcomes, but evidence of vertical transmission remains limited.[SUP]1-3[/SUP] Concerns regarding transplacental transmission are heightened by the ongoing clade Ib mpox epidemic, which often affects persons of reproductive age.[SUP]4[/SUP] We report three cases of clade Ib MPXV infection in pregnant women in whom we assessed molecular and histopathological evidence of transplacental transmission across all trimesters. Details of the methods, clinical presentation, and histopathological testing are provided in the Supplementary Appendix, available with the full text of this letter at NEJM.org.
...
https://www.nejm.org/doi/full/10.1056/NEJMc2503347