tetano
Editor, Senior Moderator
Thorac Cardiovasc Surg Rep
. 2022 Mar 2;11(1):e23-e26.
doi: 10.1055/s-0042-1742714. eCollection 2022 Jan.
Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 Infection
Achim Koch[SUP] 1 [/SUP], Nikolaus Pizanis[SUP] 1 [/SUP], Vasiliki Bessa[SUP] 2 [/SUP], Frank Herbstreit[SUP] 3 [/SUP], Erich Gulbins[SUP] 4 [/SUP], Clemens Aigner[SUP] 5 [/SUP], Markus Kamler[SUP] 6 7 [/SUP]
Affiliations
Abstract
Background The majority of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection present mild symptoms. However, some patients develop severe acute respiratory distress syndrome (ARDS) and subsequent irreversible lung damage despite extracorporeal membrane oxygenation, leaving lung transplantation the ultimate therapeutically option. Case Description Here, we report a case of lung transplantation in a 31-year-old male recipient suffering from post-coronavirus disease 2019 respiratory failure with irreversible ARDS after prolonged extracorporeal membrane oxygenation therapy. Conclusion Patient selection criteria are elucidated. One relevant mechanism for susceptibility to SARS-CoV-2 in the respiratory system, the acid sphingomyelinase/ceramide system might be altered during infection with SARS-CoV-2.
Keywords: SARS-CoV-2; lung transplantation; sphingosine.
. 2022 Mar 2;11(1):e23-e26.
doi: 10.1055/s-0042-1742714. eCollection 2022 Jan.
Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 Infection
Achim Koch[SUP] 1 [/SUP], Nikolaus Pizanis[SUP] 1 [/SUP], Vasiliki Bessa[SUP] 2 [/SUP], Frank Herbstreit[SUP] 3 [/SUP], Erich Gulbins[SUP] 4 [/SUP], Clemens Aigner[SUP] 5 [/SUP], Markus Kamler[SUP] 6 7 [/SUP]
Affiliations
- PMID: 35251890
- PMCID: PMC8890928
- DOI: 10.1055/s-0042-1742714
Abstract
Background The majority of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection present mild symptoms. However, some patients develop severe acute respiratory distress syndrome (ARDS) and subsequent irreversible lung damage despite extracorporeal membrane oxygenation, leaving lung transplantation the ultimate therapeutically option. Case Description Here, we report a case of lung transplantation in a 31-year-old male recipient suffering from post-coronavirus disease 2019 respiratory failure with irreversible ARDS after prolonged extracorporeal membrane oxygenation therapy. Conclusion Patient selection criteria are elucidated. One relevant mechanism for susceptibility to SARS-CoV-2 in the respiratory system, the acid sphingomyelinase/ceramide system might be altered during infection with SARS-CoV-2.
Keywords: SARS-CoV-2; lung transplantation; sphingosine.