tetano
Editor, Senior Moderator
Ther Apher Dial
. 2023 May 12.
doi: 10.1111/1744-9987.14001. Online ahead of print. Evaluation of clinical features and laboratory findings in critical intensive care unit patients with severe coronavirus disease-19 who underwent extracorporeal cytokine adsorption
Tunzala Yavuz[SUP] 1 2 [/SUP], Semiha Orhan[SUP] 1 [/SUP], Kazim Rollas[SUP] 2 [/SUP], Cansu Koseoglu Toksoy[SUP] 3 [/SUP], Elif Dizen Kazan[SUP] 4 [/SUP], Erhan Bozkurt[SUP] 4 [/SUP], İbrahim Guven Cosgun[SUP] 5 [/SUP], Filiz Yavasoglu[SUP] 4 [/SUP]
Affiliations
Aim: To evaluate the inflammatory parameters and oxygenation in severe coronavirus disease-19 patients who underwent extracorporeal cytokine adsorption (CA).
Methods: Patients who underwent extracorporeal CA for cytokine storm were included in the study. The changes in oxygenation, laboratory parameters, and mortality rates were investigated.
Results: Thirty-six patients were included in the study. The hemoglobin, thrombocyte, and C-reactive protein (CRP) decreased, and PaO[SUB]2[/SUB] /FiO[SUB]2[/SUB] ratio increased (p < 0.001; p < 0.01; p < 0.001; p = 0.04, respectively). Twelve (33.3%) patients received a single session, 24 (66.6%) received 2 or more sessions. CRP and fibrinogen levels decreased, and PaO[SUB]2[/SUB] /FIO[SUB]2[/SUB] ratio increased in the single session group (p = 0.04; p = 0.04; p = 0.01, respectively). In the multi-session group, the hemoglobin, platelet, procalcitonin, and CRP levels decreased, and PaO[SUB]2[/SUB] /FIO[SUB]2[/SUB] ratio increased (p < 0.01; p = 0.02; p = 0.02; p < 0.01; p = 0.01, respectively). Day 15, 30, and 90 mortality rates were 61.1%, 83.3%, and 88.9%.
Conclusion: CA with hemoperfusion reduced CRP and improved oxygenation; however, mortality rates were high.
Keywords: COVID-19; hemoperfusion; inflammation.
. 2023 May 12.
doi: 10.1111/1744-9987.14001. Online ahead of print. Evaluation of clinical features and laboratory findings in critical intensive care unit patients with severe coronavirus disease-19 who underwent extracorporeal cytokine adsorption
Tunzala Yavuz[SUP] 1 2 [/SUP], Semiha Orhan[SUP] 1 [/SUP], Kazim Rollas[SUP] 2 [/SUP], Cansu Koseoglu Toksoy[SUP] 3 [/SUP], Elif Dizen Kazan[SUP] 4 [/SUP], Erhan Bozkurt[SUP] 4 [/SUP], İbrahim Guven Cosgun[SUP] 5 [/SUP], Filiz Yavasoglu[SUP] 4 [/SUP]
Affiliations
- PMID: 37177852
- DOI: 10.1111/1744-9987.14001
Aim: To evaluate the inflammatory parameters and oxygenation in severe coronavirus disease-19 patients who underwent extracorporeal cytokine adsorption (CA).
Methods: Patients who underwent extracorporeal CA for cytokine storm were included in the study. The changes in oxygenation, laboratory parameters, and mortality rates were investigated.
Results: Thirty-six patients were included in the study. The hemoglobin, thrombocyte, and C-reactive protein (CRP) decreased, and PaO[SUB]2[/SUB] /FiO[SUB]2[/SUB] ratio increased (p < 0.001; p < 0.01; p < 0.001; p = 0.04, respectively). Twelve (33.3%) patients received a single session, 24 (66.6%) received 2 or more sessions. CRP and fibrinogen levels decreased, and PaO[SUB]2[/SUB] /FIO[SUB]2[/SUB] ratio increased in the single session group (p = 0.04; p = 0.04; p = 0.01, respectively). In the multi-session group, the hemoglobin, platelet, procalcitonin, and CRP levels decreased, and PaO[SUB]2[/SUB] /FIO[SUB]2[/SUB] ratio increased (p < 0.01; p = 0.02; p = 0.02; p < 0.01; p = 0.01, respectively). Day 15, 30, and 90 mortality rates were 61.1%, 83.3%, and 88.9%.
Conclusion: CA with hemoperfusion reduced CRP and improved oxygenation; however, mortality rates were high.
Keywords: COVID-19; hemoperfusion; inflammation.