tetano
Editor, Senior Moderator
Ther Apher Dial
. 2025 Aug 4.
doi: 10.1111/1744-9987.70071. Online ahead of print. Continuous Kidney Replacement Therapy and Outcomes of Severe Coronavirus Disease 2019 Treated With Extracorporeal Membrane Oxygenation
Yoshito Izutani[SUP] 1 [/SUP], Yasumasa Kawano[SUP] 1 2 [/SUP], Akihiro Fujita[SUP] 1 [/SUP], Shinichi Morimoto[SUP] 1 [/SUP], Kentaro Muranishi[SUP] 1 [/SUP], Kota Hoshino[SUP] 1 3 4 [/SUP], Junichi Maruyama[SUP] 1 [/SUP], Maiko Nakashio[SUP] 1 [/SUP], Junta Noake[SUP] 1 [/SUP], Hiroki Hatomoto[SUP] 5 [/SUP], Shintaro Yamasaki[SUP] 5 [/SUP], Kazuya Yamauchi[SUP] 5 [/SUP], Jun Hamaguchi[SUP] 6 [/SUP], Naofumi Bunya[SUP] 7 [/SUP], Ryuichi Nakayama[SUP] 7 8 [/SUP], Keiki Shimizu[SUP] 6 [/SUP], Yoshihiko Nakamura[SUP] 1 [/SUP]
Affiliations
Introduction: Although continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI) management is common, its effect on the outcomes of patients treated with extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) remains unclear. Therefore, we aimed to investigate the impact of CKRT on the outcomes of these patients.
Methods: Using a database of patients with severe COVID-19 who required venovenous ECMO across three centers in Japan, we assessed demographics, clinical parameters, and in-hospital mortality rates from January 2020 to December 2021.
Results: Data of 122 patients treated with ECMO for COVID-19 were analyzed. Forty-five patients required CKRT; the in-hospital mortality rate was 28.7%. Multivariate analysis showed age and CKRT were independent risk factors for in-hospital mortality. The in-hospital mortality rate was significantly higher in the CKRT group.
Conclusion: CKRT was associated with significantly high in-hospital mortality in patients treated with ECMO for severe COVID-19.
Keywords: acute kidney injury; acute respiratory distress syndrome; continuous renal replacement therapy; extracorporeal membrane oxygenation; hospital mortality.
. 2025 Aug 4.
doi: 10.1111/1744-9987.70071. Online ahead of print. Continuous Kidney Replacement Therapy and Outcomes of Severe Coronavirus Disease 2019 Treated With Extracorporeal Membrane Oxygenation
Yoshito Izutani[SUP] 1 [/SUP], Yasumasa Kawano[SUP] 1 2 [/SUP], Akihiro Fujita[SUP] 1 [/SUP], Shinichi Morimoto[SUP] 1 [/SUP], Kentaro Muranishi[SUP] 1 [/SUP], Kota Hoshino[SUP] 1 3 4 [/SUP], Junichi Maruyama[SUP] 1 [/SUP], Maiko Nakashio[SUP] 1 [/SUP], Junta Noake[SUP] 1 [/SUP], Hiroki Hatomoto[SUP] 5 [/SUP], Shintaro Yamasaki[SUP] 5 [/SUP], Kazuya Yamauchi[SUP] 5 [/SUP], Jun Hamaguchi[SUP] 6 [/SUP], Naofumi Bunya[SUP] 7 [/SUP], Ryuichi Nakayama[SUP] 7 8 [/SUP], Keiki Shimizu[SUP] 6 [/SUP], Yoshihiko Nakamura[SUP] 1 [/SUP]
Affiliations
- PMID: 40759585
- DOI: 10.1111/1744-9987.70071
Introduction: Although continuous kidney replacement therapy (CKRT) for acute kidney injury (AKI) management is common, its effect on the outcomes of patients treated with extracorporeal membrane oxygenation (ECMO) for severe coronavirus disease 2019 (COVID-19) remains unclear. Therefore, we aimed to investigate the impact of CKRT on the outcomes of these patients.
Methods: Using a database of patients with severe COVID-19 who required venovenous ECMO across three centers in Japan, we assessed demographics, clinical parameters, and in-hospital mortality rates from January 2020 to December 2021.
Results: Data of 122 patients treated with ECMO for COVID-19 were analyzed. Forty-five patients required CKRT; the in-hospital mortality rate was 28.7%. Multivariate analysis showed age and CKRT were independent risk factors for in-hospital mortality. The in-hospital mortality rate was significantly higher in the CKRT group.
Conclusion: CKRT was associated with significantly high in-hospital mortality in patients treated with ECMO for severe COVID-19.
Keywords: acute kidney injury; acute respiratory distress syndrome; continuous renal replacement therapy; extracorporeal membrane oxygenation; hospital mortality.