tetano
Editor, Senior Moderator
Emerg Infect Dis. 2010 Jun;16(6):1023.
The wages of original antigenic sin.
Morens DM, Burke DS, Halstead SB.
National Institutes of Health, Bethesda, Maryland, USA, and Associate Editor, Emerging Infectious Diseases (D.M. Morens); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA, and former Editorial Board member, Emerging Infectious Diseases (D.S. Burke); and Uniformed Services University of the Health Sciences, Bethesda, and Editorial Board, Emerging Infectious Diseases (S.B. Halstead).
Abstract
"The deliberate sin of the first man is the cause of original sin" -[Saint] Augustine of Hippo, Algerian Christian theologian (354 ad-430 ad), De nuptiis et concupiscientia [On Marriage and Concupiscence], II, xxvi, 43 What epidemiologist Thomas Francis, Jr. (1900-1969) was thinking when pondering certain inexplicable serologic data from a 1946 influenza vaccine trial may never be known. Whether in religious reverence for the beauty of science or impish delight fueled by the martini breaks of which he was so fond, Francis coined the term "original antigenic sin" to describe a curious new immunologic phenomenon. Elsewhere in this issue, Adalja and Henderson propose that original antigenic sin has altered the population age-specific incidence of infection and disease caused by influenza A pandemic (H1N1) 2009 virus and that public health responses must account for the disruption (1). What is original antigenic sin, what is its immunologic basis, and into what sort of trouble is it getting us?
PMID: 20507764 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/20507764
The wages of original antigenic sin.
Morens DM, Burke DS, Halstead SB.
National Institutes of Health, Bethesda, Maryland, USA, and Associate Editor, Emerging Infectious Diseases (D.M. Morens); University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA, and former Editorial Board member, Emerging Infectious Diseases (D.S. Burke); and Uniformed Services University of the Health Sciences, Bethesda, and Editorial Board, Emerging Infectious Diseases (S.B. Halstead).
Abstract
"The deliberate sin of the first man is the cause of original sin" -[Saint] Augustine of Hippo, Algerian Christian theologian (354 ad-430 ad), De nuptiis et concupiscientia [On Marriage and Concupiscence], II, xxvi, 43 What epidemiologist Thomas Francis, Jr. (1900-1969) was thinking when pondering certain inexplicable serologic data from a 1946 influenza vaccine trial may never be known. Whether in religious reverence for the beauty of science or impish delight fueled by the martini breaks of which he was so fond, Francis coined the term "original antigenic sin" to describe a curious new immunologic phenomenon. Elsewhere in this issue, Adalja and Henderson propose that original antigenic sin has altered the population age-specific incidence of infection and disease caused by influenza A pandemic (H1N1) 2009 virus and that public health responses must account for the disruption (1). What is original antigenic sin, what is its immunologic basis, and into what sort of trouble is it getting us?
PMID: 20507764 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/20507764