tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2013 Aug 27;10(1). [Epub ahead of print]
The type of adjuvant strongly influences the T-cell response during nanoparticle-based immunization.
Knuschke T, Epple M, Westendorf AM.
Source
Infection Immunology; Institute of Medical Microbiology; University Hospital Essen; University of Duisburg-Essen; Essen, Germany.
Abstract
Potent vaccines require the ability to effectively induce immune responses. Especially for the control of infectious diseases with intracellular pathogens, like viruses or bacteria, potent T-cell responses are indispensable. Several delivery systems such as nanoparticles have been considered to boost the immunogenicity of pathogen derived peptides or subunits for the induction of potent T-cell responses. Since they can be further functionalized with immunostimulants, like Toll-like receptor (TLR) agonists, they improve the response by enhanced activation of the innate immune system. Currently, TLR agonists like unmethylated CpG oligonucleotides and the synthetic dsRNA derivate polyriboinosinic acid-polyribocytidylic acid (poly[I:C]) are widely used as vaccine adjuvants. CpG and poly(I:C) trigger different TLRs and therefore show differential signal transduction. Recently, we established biodegradable calcium phosphate (CaP) nanoparticles as potent T cell inducing vaccination vehicles. In this commentary we discuss the role of CpG and poly(I:C) for the effective induction of virus-specific T cells during immunization with CaP nanoparticles. The presented results underline the importance of the right formulation of vaccines for specific immunization purpose.
KEYWORDS:
T-cell immunity, calcium phosphate, influenza virus, nanoparticles, vaccine
PMID:
23982325
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23982325
The type of adjuvant strongly influences the T-cell response during nanoparticle-based immunization.
Knuschke T, Epple M, Westendorf AM.
Source
Infection Immunology; Institute of Medical Microbiology; University Hospital Essen; University of Duisburg-Essen; Essen, Germany.
Abstract
Potent vaccines require the ability to effectively induce immune responses. Especially for the control of infectious diseases with intracellular pathogens, like viruses or bacteria, potent T-cell responses are indispensable. Several delivery systems such as nanoparticles have been considered to boost the immunogenicity of pathogen derived peptides or subunits for the induction of potent T-cell responses. Since they can be further functionalized with immunostimulants, like Toll-like receptor (TLR) agonists, they improve the response by enhanced activation of the innate immune system. Currently, TLR agonists like unmethylated CpG oligonucleotides and the synthetic dsRNA derivate polyriboinosinic acid-polyribocytidylic acid (poly[I:C]) are widely used as vaccine adjuvants. CpG and poly(I:C) trigger different TLRs and therefore show differential signal transduction. Recently, we established biodegradable calcium phosphate (CaP) nanoparticles as potent T cell inducing vaccination vehicles. In this commentary we discuss the role of CpG and poly(I:C) for the effective induction of virus-specific T cells during immunization with CaP nanoparticles. The presented results underline the importance of the right formulation of vaccines for specific immunization purpose.
KEYWORDS:
T-cell immunity, calcium phosphate, influenza virus, nanoparticles, vaccine
PMID:
23982325
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23982325