tetano
Editor, Senior Moderator
Clin Infect Dis. 2017 Apr 29. doi: 10.1093/clinid/cix412. [Epub ahead of print]
[h=1]The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance from Australia 2013-2015.[/h] Britton PN[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Blyth CC[SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Macartney K[SUP]1,[/SUP][SUP]3,[/SUP][SUP]7[/SUP], Dale RC[SUP]1,[/SUP][SUP]3[/SUP], Li-Kim-Moy J[SUP]3,[/SUP][SUP]7[/SUP], Khandaker G[SUP]1,[/SUP][SUP]7[/SUP], Crawford N[SUP]8,[/SUP][SUP]9[/SUP], Marshall H[SUP]10[/SUP], Clark J[SUP]11,[/SUP][SUP]12[/SUP], Elliott E[SUP]1,[/SUP][SUP]13[/SUP], Booy R[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]7[/SUP], Cheng AC[SUP]14,[/SUP][SUP]15[/SUP], Jones CA[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]8,[/SUP][SUP]9[/SUP]; ACE study investigators, FluCAN investigators and PAEDS network..
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background.:[/h] There are few longitudinal studies of seasonal influenza associated neurological disease (IAND) and none from the Southern hemisphere.
[h=4]Methods.:[/h] We extracted prospectively acquired Australian surveillance data from two studies nested within the Paediatric Active Enhanced Disease Surveillance (PAEDS) network: the Influenza Complications Alert Network (FluCAN) study and the Australian Childhood Encephalitis (ACE) study between 2013 and 2015. We described the clinical features and severity of IAND in children, including influenza associated encephalitis/encephalopathy (IAE). We calculated the proportion of hospitalised influenza that is associated with IAND and IAE, and incidence of IAE.
[h=4]Results.:[/h] Over three influenza seasons, we identified 54 cases of IAND at two tertiary children's hospitals from Australia that accounted for 7.6% of hospitalised influenza. These included 10 cases of IAE (1.4% hospitalised influenza). The mean annual incidence of IAE amongst Australian children (aged ≤14 years) was 2.8 per 1 000 000. The spectrum of IAND was broad and included: IAE (10) including distinct acute encephalopathy syndromes, simple febrile seizures (14), other seizures (16), acute ataxia (4), and other sub-acute syndromes (transverse myelitis (1), opsoclonus myoclonus (1)). Two thirds of children with IAND were aged ≤4 years; less than half had pre-existing neurological disease or other risk factors for severe influenza. IAE caused death or neurological morbidity in half of cases.
[h=4]Conclusions.:[/h] Seasonal influenza is an important cause of acute neurological disease in Australian children. The spectrum of seasonal IAND appears similar to that described during the 2009 H1N1 pandemic. IAE is associated with high morbidity and mortality.
[h=4]KEYWORDS:[/h] Influenza; encephalitis; encephalopathy; seizures; surveillance
PMID: 28460008 DOI: 10.1093/clinid/cix412
[h=1]The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance from Australia 2013-2015.[/h] Britton PN[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3[/SUP], Blyth CC[SUP]4,[/SUP][SUP]5,[/SUP][SUP]6[/SUP], Macartney K[SUP]1,[/SUP][SUP]3,[/SUP][SUP]7[/SUP], Dale RC[SUP]1,[/SUP][SUP]3[/SUP], Li-Kim-Moy J[SUP]3,[/SUP][SUP]7[/SUP], Khandaker G[SUP]1,[/SUP][SUP]7[/SUP], Crawford N[SUP]8,[/SUP][SUP]9[/SUP], Marshall H[SUP]10[/SUP], Clark J[SUP]11,[/SUP][SUP]12[/SUP], Elliott E[SUP]1,[/SUP][SUP]13[/SUP], Booy R[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]7[/SUP], Cheng AC[SUP]14,[/SUP][SUP]15[/SUP], Jones CA[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]8,[/SUP][SUP]9[/SUP]; ACE study investigators, FluCAN investigators and PAEDS network..
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background.:[/h] There are few longitudinal studies of seasonal influenza associated neurological disease (IAND) and none from the Southern hemisphere.
[h=4]Methods.:[/h] We extracted prospectively acquired Australian surveillance data from two studies nested within the Paediatric Active Enhanced Disease Surveillance (PAEDS) network: the Influenza Complications Alert Network (FluCAN) study and the Australian Childhood Encephalitis (ACE) study between 2013 and 2015. We described the clinical features and severity of IAND in children, including influenza associated encephalitis/encephalopathy (IAE). We calculated the proportion of hospitalised influenza that is associated with IAND and IAE, and incidence of IAE.
[h=4]Results.:[/h] Over three influenza seasons, we identified 54 cases of IAND at two tertiary children's hospitals from Australia that accounted for 7.6% of hospitalised influenza. These included 10 cases of IAE (1.4% hospitalised influenza). The mean annual incidence of IAE amongst Australian children (aged ≤14 years) was 2.8 per 1 000 000. The spectrum of IAND was broad and included: IAE (10) including distinct acute encephalopathy syndromes, simple febrile seizures (14), other seizures (16), acute ataxia (4), and other sub-acute syndromes (transverse myelitis (1), opsoclonus myoclonus (1)). Two thirds of children with IAND were aged ≤4 years; less than half had pre-existing neurological disease or other risk factors for severe influenza. IAE caused death or neurological morbidity in half of cases.
[h=4]Conclusions.:[/h] Seasonal influenza is an important cause of acute neurological disease in Australian children. The spectrum of seasonal IAND appears similar to that described during the 2009 H1N1 pandemic. IAE is associated with high morbidity and mortality.
[h=4]KEYWORDS:[/h] Influenza; encephalitis; encephalopathy; seizures; surveillance
PMID: 28460008 DOI: 10.1093/clinid/cix412