tetano
Editor, Senior Moderator
J Infect Dis. 2012 Jul 12. [Epub ahead of print]
The relationship between influenza outbreaks and acute ischemic heart disease in Maryland residents over a seven-year period.
Lichenstein R, Magder LS, King RE, King JC Jr.
Source
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, U.S.A.
Abstract
Background. We sought to expand the understanding of relationships of influenza outbreaks to ischemic heart disease (IHD)-related events.Methods. Retrospective data sources were utilized to examine relationships of intense influenza outbreak periods (intense-IOP) to rates of IHD-related hospitalizations and deaths for Maryland residents aged 50 years or older. Rate ratios (RR) were calculated for medical outcomes during intense-IOP compared to non-IOP for seven years.Results. RR for IHD-related hospitalizations (RR = 1.06), deaths (RR = 1.16) and combined hospitalizations for IHD- and medically attended acute respiratory illness (MAARI) (RR = 1.42) were significantly elevated during intense-IOP over the seven years (P < 0.01). RR for IHD-related hospitalizations increased significantly with age (P = 0.0007). Also, RR for IHD-related hospitalizations each year were significantly correlated to proportions of circulating A/H3N2 viruses in that year (CC = 0.83, P = 0.02). Finally, for residents aged 65 years or older, RR for IHD-related hospitalizations each year were significantly correlated with magnitude of the intense-IOPs in that year as measured by RRs for MAARI-related emergency department visits (CC = 0.77, P = 0.04).Conclusions. These data suggest that influenza infections, particularly by A/H3N2 viruses, are directly associated with acute IHD-related events in older individuals.
PMID:
22798684
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22798684
The relationship between influenza outbreaks and acute ischemic heart disease in Maryland residents over a seven-year period.
Lichenstein R, Magder LS, King RE, King JC Jr.
Source
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, U.S.A.
Abstract
Background. We sought to expand the understanding of relationships of influenza outbreaks to ischemic heart disease (IHD)-related events.Methods. Retrospective data sources were utilized to examine relationships of intense influenza outbreak periods (intense-IOP) to rates of IHD-related hospitalizations and deaths for Maryland residents aged 50 years or older. Rate ratios (RR) were calculated for medical outcomes during intense-IOP compared to non-IOP for seven years.Results. RR for IHD-related hospitalizations (RR = 1.06), deaths (RR = 1.16) and combined hospitalizations for IHD- and medically attended acute respiratory illness (MAARI) (RR = 1.42) were significantly elevated during intense-IOP over the seven years (P < 0.01). RR for IHD-related hospitalizations increased significantly with age (P = 0.0007). Also, RR for IHD-related hospitalizations each year were significantly correlated to proportions of circulating A/H3N2 viruses in that year (CC = 0.83, P = 0.02). Finally, for residents aged 65 years or older, RR for IHD-related hospitalizations each year were significantly correlated with magnitude of the intense-IOPs in that year as measured by RRs for MAARI-related emergency department visits (CC = 0.77, P = 0.04).Conclusions. These data suggest that influenza infections, particularly by A/H3N2 viruses, are directly associated with acute IHD-related events in older individuals.
PMID:
22798684
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22798684