tetano
Editor, Senior Moderator
J Gen Virol. 2015 Nov 11. doi: 10.1099/jgv.0.000333. [Epub ahead of print]
[h=1]The PB2 subunit of avian influenza virus of subtype H9N2: a pandemic risk factor.[/h] Sediri H[SUP]1[/SUP], Thiele S[SUP]2[/SUP], Schwalm F[SUP]3[/SUP], Gabriel G[SUP]4[/SUP], Klenk HD[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Avian influenza viruses of subtype H9N2 that are spread over the world are occasionally transmitted to humans and pigs. Furthermore, by co-circulating with other influenza subtypes, they can generate new viruses with the potential to cause also zoonotic infections as observed in 1997 with H5N1 or more recently with H7N9 and H10N8 viruses. Comparative analysis of the adaptive mutations in polymerases of different viruses indicates that their impact on the phylogenetically related H9N2 and H7N9 polymerases is higher than on the non-related H7N7 and H1N1pdm09 polymerases. Analysis of polymerase reassortants composed of subunits of different viruses demonstrates that the efficient enhancement of the polymerase activity by H9N2-PB2 does not depend on PA and PB1. These observations suggest that the PB2 subunit of the H9N2 polymerase has a high adaptive potential and may therefore be an important pandemic risk factor.
PMID: 26560088 [PubMed - as supplied by publisher]
[h=1]The PB2 subunit of avian influenza virus of subtype H9N2: a pandemic risk factor.[/h] Sediri H[SUP]1[/SUP], Thiele S[SUP]2[/SUP], Schwalm F[SUP]3[/SUP], Gabriel G[SUP]4[/SUP], Klenk HD[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Avian influenza viruses of subtype H9N2 that are spread over the world are occasionally transmitted to humans and pigs. Furthermore, by co-circulating with other influenza subtypes, they can generate new viruses with the potential to cause also zoonotic infections as observed in 1997 with H5N1 or more recently with H7N9 and H10N8 viruses. Comparative analysis of the adaptive mutations in polymerases of different viruses indicates that their impact on the phylogenetically related H9N2 and H7N9 polymerases is higher than on the non-related H7N7 and H1N1pdm09 polymerases. Analysis of polymerase reassortants composed of subunits of different viruses demonstrates that the efficient enhancement of the polymerase activity by H9N2-PB2 does not depend on PA and PB1. These observations suggest that the PB2 subunit of the H9N2 polymerase has a high adaptive potential and may therefore be an important pandemic risk factor.
PMID: 26560088 [PubMed - as supplied by publisher]