tetano
Editor, Senior Moderator
J Gen Virol. 2014 Jul 29. pii: vir.0.068569-0. doi: 10.1099/vir.0.068569-0. [Epub ahead of print]
The origin of the European avian-like swine influenza viruses.
Krumbholz A1, Lange J1, Sauerbrei A1, Groth M2, Platzer M2, Kanrai P3, Pleschka S3, Scholtissek C3, B?ttner M4, D?rrwald R5, Zell R6.
Author information
Abstract
The avian-like swine influenza viruses emerged in 1979 in Belgium and Germany. Thereafter, they spread through many European swine-producing countries, replaced the circulating classical swine H1N1 influenza viruses and became endemic. Serological and subsequent molecular data indicated an avian source, but details remained obscure due to a lack of relevant avian influenza virus sequence data. Here, the origin of the European avian-like swine influenza viruses was analyzed using a collection of sixteen European swine H1N1 influenza viruses sampled in 1979-1981 in Germany, the Netherlands, Belgium, Italy and France as well as several contemporaneous avian influenza viruses of various serotypes. The phylogenetic trees suggest a triple reassortant with a unique genotype constellation. Time-resolved maximum clade credibility trees indicate times to the most recent common ancestors of 34-46 years (before 2008) depending on the RNA segment and the method of tree inference.
Copyright ? 2014, the Society for General Microbiology.
KEYWORDS:
H1N1; Illumina next generation sequencing; avian-like swine influenza virus; influenza virus evolution; transspecies infection
PMID:
25073465
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25073465
The origin of the European avian-like swine influenza viruses.
Krumbholz A1, Lange J1, Sauerbrei A1, Groth M2, Platzer M2, Kanrai P3, Pleschka S3, Scholtissek C3, B?ttner M4, D?rrwald R5, Zell R6.
Author information
Abstract
The avian-like swine influenza viruses emerged in 1979 in Belgium and Germany. Thereafter, they spread through many European swine-producing countries, replaced the circulating classical swine H1N1 influenza viruses and became endemic. Serological and subsequent molecular data indicated an avian source, but details remained obscure due to a lack of relevant avian influenza virus sequence data. Here, the origin of the European avian-like swine influenza viruses was analyzed using a collection of sixteen European swine H1N1 influenza viruses sampled in 1979-1981 in Germany, the Netherlands, Belgium, Italy and France as well as several contemporaneous avian influenza viruses of various serotypes. The phylogenetic trees suggest a triple reassortant with a unique genotype constellation. Time-resolved maximum clade credibility trees indicate times to the most recent common ancestors of 34-46 years (before 2008) depending on the RNA segment and the method of tree inference.
Copyright ? 2014, the Society for General Microbiology.
KEYWORDS:
H1N1; Illumina next generation sequencing; avian-like swine influenza virus; influenza virus evolution; transspecies infection
PMID:
25073465
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25073465