tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2017 Dec 15. doi: 10.1111/irv.12492. [Epub ahead of print]
[h=1]The national burden of influenza-associated severe acute respiratory illness hospitalization in Zambia, 2011-2014.[/h] Theo A[SUP]1[/SUP], Tempia S[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Cohen AL[SUP]1,[/SUP][SUP]5[/SUP], Simusika P[SUP]6[/SUP], Chentulo E[SUP]6[/SUP], Chikamukwa CM[SUP]7[/SUP], Monze M[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Estimates of influenza-associated hospitalization are limited in low- and middle-income countries, especially in Africa.
[h=4]OBJECTIVE:[/h] To estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Zambia.
[h=4]METHODS:[/h] We conducted active prospective hospital-based surveillance for SARI at the University Teaching Hospital (UTH) situated in Lusaka Province during 2011-2014. Upper respiratory tract samples were tested for influenza virus using a reverse transcriptase polymerase chain reaction assay. We estimated age-specific rates of influenza-associated SARI hospitalizations for the UTH using census and secondary data on respiratory hospitalizations following estimation approaches recommended by the World Health Organization. We used the UTH hospitalization rates as a proxy for Lusaka Province. These rates were adjusted for each of the remaining 9 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. Rates were expressed per 100,000 population.
[h=4]RESULTS:[/h] SARI cases accounted for 77.1% (13 389/17 354) of respiratory admissions at the UTH; 82.7% (11 859/14 344) and 50.8% (1530/3010) among individuals aged <5 and ≥5 years, respectively. Among SARI cases tested, the influenza virus detection rate was 5.5% (152/2734), 4.8% (48/998), and 6.0% (104/1736) among individuals aged <5 and ≥5 years, respectively. The mean annual national number of influenza-associated SARI hospitalizations was 6181 (95% CI: 4321-8041-rate: 43.9; 95% CI: 30.7-57.1); 4669 (95% CI: 3287-6051-rate: 187.7; 95% CI: 132.1-243.3) among children aged <5 years; and 1512 (95% CI: 1037-1987-rate: 13.1; 95% CI: 9.0-17.2) among individuals aged ≥5 years.
[h=4]CONCLUSIONS:[/h] The burden of influenza-associated SARI hospitalizations was substantial and was highest among children aged <5 years.
? 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] Zambia; burden; hospitalization; influenza; severe acute respiratory illness
PMID: 29243406 DOI: 10.1111/irv.12492
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[h=1]The national burden of influenza-associated severe acute respiratory illness hospitalization in Zambia, 2011-2014.[/h] Theo A[SUP]1[/SUP], Tempia S[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Cohen AL[SUP]1,[/SUP][SUP]5[/SUP], Simusika P[SUP]6[/SUP], Chentulo E[SUP]6[/SUP], Chikamukwa CM[SUP]7[/SUP], Monze M[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Estimates of influenza-associated hospitalization are limited in low- and middle-income countries, especially in Africa.
[h=4]OBJECTIVE:[/h] To estimate the national number of influenza-associated severe acute respiratory illness (SARI) hospitalization in Zambia.
[h=4]METHODS:[/h] We conducted active prospective hospital-based surveillance for SARI at the University Teaching Hospital (UTH) situated in Lusaka Province during 2011-2014. Upper respiratory tract samples were tested for influenza virus using a reverse transcriptase polymerase chain reaction assay. We estimated age-specific rates of influenza-associated SARI hospitalizations for the UTH using census and secondary data on respiratory hospitalizations following estimation approaches recommended by the World Health Organization. We used the UTH hospitalization rates as a proxy for Lusaka Province. These rates were adjusted for each of the remaining 9 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. Rates were expressed per 100,000 population.
[h=4]RESULTS:[/h] SARI cases accounted for 77.1% (13 389/17 354) of respiratory admissions at the UTH; 82.7% (11 859/14 344) and 50.8% (1530/3010) among individuals aged <5 and ≥5 years, respectively. Among SARI cases tested, the influenza virus detection rate was 5.5% (152/2734), 4.8% (48/998), and 6.0% (104/1736) among individuals aged <5 and ≥5 years, respectively. The mean annual national number of influenza-associated SARI hospitalizations was 6181 (95% CI: 4321-8041-rate: 43.9; 95% CI: 30.7-57.1); 4669 (95% CI: 3287-6051-rate: 187.7; 95% CI: 132.1-243.3) among children aged <5 years; and 1512 (95% CI: 1037-1987-rate: 13.1; 95% CI: 9.0-17.2) among individuals aged ≥5 years.
[h=4]CONCLUSIONS:[/h] The burden of influenza-associated SARI hospitalizations was substantial and was highest among children aged <5 years.
? 2017 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] Zambia; burden; hospitalization; influenza; severe acute respiratory illness
PMID: 29243406 DOI: 10.1111/irv.12492
Free full text