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The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

tetano

tetano

Editor, Senior Moderator
The Lancet, Volume 381, Issue 9883, Page 2134, 15 June 2013
<Previous Article
doi:10.1016/S0140-6736(13)61135-6Cite or Link Using DOI
Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China
Yefei Zhu PhD a, Xian Qi PhD a, Lunbiao Cui a, Minghao Zhou PhD a, Prof Hua Wang MD a Corresponding AuthorEmail Address
In February, 2013, a novel avian influenza A H7N9 virus emerged in east China and quickly spread to other areas. 1?3 By May 27, 130 human infections had been confirmed, with 37 deaths. Transmission can occur through direct or close contact with poultry or through exposure to environments that are contaminated with poultry. No human-to-human transmission has been reported. Co-infection of viruses in human beings, birds, or other animals provides the possibility for the emergence of a new reassortan ...


http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61135-6/fulltext
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

did it reassort ? yes or no, 1 bit of information

Purchase this article for $31.50
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

The price was my problem too!!!
I hope someone posts the highlights and case patient! ::(
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

CIDRAP commentary reports-
H7N9-H3N2 coinfection reported in Chinese teen
Chinese researchers today reported a case of coinfection with H3N2 and H7N9 influenza in a 15-year-old boy from Jiangsu province who was sick in late April and quickly recovered. The team published a case report on their findings in today's issue of The Lancet. The previously health student started having symptoms on Apr 25 and went to the hospital the next day when they worsened. Two throat swabs were taken, and rapid testing showed influenza A. Polymerase chain reaction (PCR) testing in Nanjing indicated influenza A, H7, and H3.
Virus isolation yielded H7N9 and H3N2 viruses. The H7N9 virus was highly similar to a Zhejiang strain, and the H3N2 virus was closely related to currently circulating seasonal H3N2 viruses, according to the report. The boy was admitted to the hospital where he received osteltamivir (Tamiflu) treatment. He recovered on May 2. Researchers wrote that dual infections are a potential source of reassortment between human and avian viral strains, which could raise the risk of human-to-human transmission.
Jun 15 Lancet abstract

http://www.cidrap.umn.edu/cidrap/content/influenza/h7n9/news/jun1413fluscan.html
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

apparently no reassortant viruses were found in this case

the H3N2 probably attenuated the H7N9 : it caused early
immune reactions and competed with H7N9 for first entry
into uninfected cells
I'm assuming H3N2 is faster here
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

Published Date: 2013-06-16 04:51:58
Subject: PRO/AH/EDR> Influenza (36): China (JS) H3N2/H7N9 coinfection
Archive Number: 20130616.1775239

INFLUENZA (36): CHINA (JIANGSU) H3N2/H7N9 COINFECTION
*****************************************************
A ProMED-mail post
http://www.promedmail.org
ProMED-mail is a program of the
International Society for Infectious Diseases
http://www.isid.org

Date: Fri 14 Jun 2013
Source: CIDRAP News [edited]
http://www.cidrap.umn.edu/cidrap/content/influenza/h7n9/news/jun1413fluscan.html


Chinese researchers today reported a case of coinfection with H3N2 and H7N9 influenza in a 15 year old boy from Jiangsu province who was sick in late April [2013] and quickly recovered. The team published a case report on their findings in today's issue of The Lancet. The previously healthy student started having symptoms on 25 Apr [2013] and went to the hospital the next day when they worsened. There, 2 throat swabs were taken, and rapid testing showed influenza A. Polymerase chain reaction (PCR) testing in Nanjing indicated influenza A, H7, and H3. Virus isolation yielded H7N9 and H3N2 viruses. The H7N9 virus was highly similar to a Zhejiang strain, and the H3N2 virus was closely related to currently circulating seasonal H3N2 viruses, according to the report. The boy was admitted to the hospital where he received oseltamivir (Tamiflu) treatment. He recovered on 2 May [2013]. Researchers wrote that dual infections are a potential source of reassortment between human and avian viral strains, which could raise the risk of human-to-human transmission.

[From: Yefei Zhu and 4 others. Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China. The Lancet 2013; 381(9883): 2134, 15 Jun, http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61135-6/fulltext.]

--
communicated by:
ProMED-mail
<promed@promedmail.org>

[In February 2013, a novel avian influenza A H7N9 virus emerged in east China and quickly spread to other areas. By 27 May 2013, 130 human infections had been confirmed, with 37 deaths. Transmission of the H7N9 virus is believed to occur through direct or close contact with poultry or through exposure to environments that are contaminated with poultry. On this occasion it is presumed that the H7H9 virus infected an individual already infected by the then current epidemic H3N2 virus. No human-to-human transmission has been reported subsequently, but coinfection of human beings, birds, or other animals provides an opportunity for the emergence of a new reassortant. The paper by Yefei Zhu and colleagues describes such a situation whereby a 15 year old boy was hospitalised and found to be coinfected by the H3N2 epidemic influenza virus and in addition by the novel avian H7N9 influenza virus. The young patient was hospitalised and recovered after a period of treatment. No onward transmission of influenza virus was detected. Nonetheless, this incident may be a forewarning of such an outcome in the future. - Mod.CP

A HealthMap/ProMED-mail map can be accessed at: http://healthmap.org/r/7j-h, http://healthmap.org/r/7j-h.]

http://beta.promedmail.org/direct.php?id=20130616.1775239
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

On 2013-05-02 Low Probability, High Impact ReAssortments [H7N9 Analysis #104] discussed the GeneWurx ranking of probability for Neuraminidase ReAssortment of emergent H7N9 with circulating human influenza serotypes during the time period discussed in the study.

sH3N2 appeared at that time to be more probable for ReAssortment than pH1N1 up to April 30th. Genetic signals (quite limited) reversed the ranking by moving pH1N1 slightly ahead of sH3N2 on or after May 1st.

However, that model is based on sub-segment promiscuity, a principle that may not directly correlate with lateral segment transfer and that cannot currently be cross-validated due to the low level of cooperation from those who hold private H7N9 data. Each circulating human serotype remains a Re-Assortment threat. Additional sequence data would be useful in predicting viability, location and timing of reassortment events.
 
Re: The Lancet: Human co-infection with novel avian influenza A H7N9 and influenza A H3N2 viruses in Jiangsu province, China

China - Southern provinces incidence of influenza abnormally high this year - mainly H3N2

Translation Google

2014-01-08
...
Disease Prevention and Control Center of Jiangsu Province as 汤奋扬 acute communicable disease control director, told reporters that the current incidence of influenza in northern basically unchanged from previous years, however, Jiangsu, Zhejiang, Guangzhou and other southern provinces, the incidence of influenza are higher than in previous years.
...
Tang Fenyang, from the pathogen monitoring, the north and south of the current influenza are different, the North is the main strain of influenza A H1N1 and type B, the southern provinces is the influenza H3N2.
...
http://www.flutrackers.com/forum/sho...d.php?t=215970
---------------------------------------------------------------------------------------------------
January 8, 2014
...
HKU infections and diseases Ho Pak-leung means the Director of the Centre , the influenza virus would weaken the respiratory tract , lungs chain more intrusion ; while the first wave of H7N9 outbreaks mainland also found that people can be infected with H7N9 and H3N2 influenza virus might display in the human body " reshuffle " , the situation can not be ignored .
...
zhttp://hk.apple.nextmedia.com/news/art/20140108/18583699
 
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