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Clin Infect Dis. 2011 Jul;53(1):100-2.
The Infection Attack Rate and Severity of 2009 Pandemic H1N1 Influenza in Hong Kong: Accuracy Amidst Ambiguity.
Kok J, Dwyer DE.
Source
Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia.
<address>Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales, Australia </address>
Correspondence: Jen Kok, MBBS, FRACP, FRCPA, Centre for Infectious Diseases and Microbiology Laboratory Services, Level 3, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW 2145, Australia (jen.kok@swahs.health.nsw.gov.au).
ARTICLE T O THE E DITOR?Wu et al report serosurvey results performed on 3 cohorts (blood donors aged 16?65 years, hospital outpatients aged 5?59 years, and children aged 5?14 years) to estimate pandemic (H1N1) 2009 influenza attack rates (IARs) after the first pandemic wave in Hong Kong [ 1]. Their serosurvey incorporated 2 different study designs: the serial cross-sectional method (estimating IARs by subtracting prepandemic from postpandemic seroprevalence rates) and demonstration of individual seroconversion in paired serum samples. Microneutralization was performed using influenza A/California/4/2009 as antigen, and seropositivity was defined as microneutralization antibody titers ≥1:40 or the demonstration of a 4-fold or greater difference between paired serum samples. Data were then stratified to determine IARs within specific age ? [Full Text of this Article]
