tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2015 Dec 9. doi: 10.1111/irv.12366. [Epub ahead of print]
[h=1]The impact of national vaccination policy changes on influenza incidence in the Netherlands.[/h] McDonald SA[SUP]1[/SUP], van Asten L[SUP]1[/SUP], van der Hoek W[SUP]1[/SUP], Donker GA[SUP]2[/SUP], Wallinga J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We assessed the impact of two major modifications of the Dutch National Influenza Prevention Programme - the introduction in 1997 of free of charge vaccination to persons aged ≥65 years and to high-risk groups (previously only advised, and not free of charge), and the lowering of the eligible age to 60 years in 2008 - on the estimated incidence of influenza infection leading to influenza-like illness (ILI).
[h=4]METHODS:[/h] Additive negative-binomial segmented regression models were fitted to ILI data from GP sentinel surveillance in two eight-season intervals (1993/4 to 2000/1, 2004/5 to 2011/12, comparing pre- and post-policy-change periods within each interval), with laboratory virological reporting of samples positive for influenza or other ILI-causing pathogens as covariates.
[h=4]RESULTS:[/h] For the 2008 policy change, there was a significant step decrease in influenza contribution considering all ages (= -111 per 100 positives; 95% CI: -162, -65.0), <60 years, and 60-64 years age-groups (B = -92.1 per 100; 95% CI: -134, -55.5; B = -5.2; 95% CI: -10.3, -1.2, respectively). There was no evidence for a decrease associated with the 1997 policy change targetting the ≥65 years age-group.
[h=4]CONCLUSIONS:[/h] In the Netherlands a 56% reduction in influenza contribution was associated with the 2008 policy targeting 60-64 year-olds, but there was no effect of the earlier policy targetting ≥65 year-olds, for whom vaccination coverage was already rising before the policy change. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Influenza-like illness; Netherlands; Statistical model; Vaccination policy
PMID: 26648343 [PubMed - as supplied by publisher] Free full text
[h=1]The impact of national vaccination policy changes on influenza incidence in the Netherlands.[/h] McDonald SA[SUP]1[/SUP], van Asten L[SUP]1[/SUP], van der Hoek W[SUP]1[/SUP], Donker GA[SUP]2[/SUP], Wallinga J[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We assessed the impact of two major modifications of the Dutch National Influenza Prevention Programme - the introduction in 1997 of free of charge vaccination to persons aged ≥65 years and to high-risk groups (previously only advised, and not free of charge), and the lowering of the eligible age to 60 years in 2008 - on the estimated incidence of influenza infection leading to influenza-like illness (ILI).
[h=4]METHODS:[/h] Additive negative-binomial segmented regression models were fitted to ILI data from GP sentinel surveillance in two eight-season intervals (1993/4 to 2000/1, 2004/5 to 2011/12, comparing pre- and post-policy-change periods within each interval), with laboratory virological reporting of samples positive for influenza or other ILI-causing pathogens as covariates.
[h=4]RESULTS:[/h] For the 2008 policy change, there was a significant step decrease in influenza contribution considering all ages (= -111 per 100 positives; 95% CI: -162, -65.0), <60 years, and 60-64 years age-groups (B = -92.1 per 100; 95% CI: -134, -55.5; B = -5.2; 95% CI: -10.3, -1.2, respectively). There was no evidence for a decrease associated with the 1997 policy change targetting the ≥65 years age-group.
[h=4]CONCLUSIONS:[/h] In the Netherlands a 56% reduction in influenza contribution was associated with the 2008 policy targeting 60-64 year-olds, but there was no effect of the earlier policy targetting ≥65 year-olds, for whom vaccination coverage was already rising before the policy change. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza; Influenza-like illness; Netherlands; Statistical model; Vaccination policy
PMID: 26648343 [PubMed - as supplied by publisher] Free full text