tetano
Editor, Senior Moderator
Viruses. 2016 Mar 7;8(3). pii: E71. doi: 10.3390/v8030071.
[h=1]The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice.[/h] Warfield KL[SUP]1[/SUP], Barnard DL[SUP]2[/SUP], Enterlein SG[SUP]3[/SUP], Smee DF[SUP]4[/SUP], Khaliq M[SUP]1[/SUP], Sampath A[SUP]5[/SUP], Callahan MV[SUP]6,[/SUP][SUP]7[/SUP], Ramstedt U[SUP]8[/SUP], Day CW[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned.
[h=4]KEYWORDS:[/h] Iminosugar; UV-4B; antiviral; human bronchial epithelial cells; influenza; mice
PMID: 27072420 [PubMed - in process] PMCID: PMC4810261 Free full text
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[TD="width: 20%, align: left"]AfrikaansAlbaneseAraboArmenoAzeroBascoBengaleseBielorussoBirmanoBosniacoBulgaroCatalanoCebuanoCecoChichewaCinese (semp)Cinese (trad)CoreanoCreolo HaitianoCroatoDaneseEbraicoEsperantoEstoneFilippinoFinlandeseFranceseGalizianoGalleseGeorgianoGiapponeseGiavaneseGrecoGujaratiHausaHindiHmongIgboIndonesianoIngleseIrlandeseIslandeseItalianoKannadaKazakoKhmerLaoLatinoLettoneLituanoMacedoneMalabareseMalagasyMaleseMalteseMaoriMaratiMongoloNepaleseNorvegeseOlandesePersianoPolaccoPortoghesePunjabiRumenoRussoSerboSesothoSingaleseSlovaccoSlovenoSomaloSpagnoloSundaneseSvedeseSwahiliTagikoTailandeseTamilTedescoTeluguTurcoUcrainoUnghereseUrduUsbecoVietnamitaYiddishYorubaZulu[/TD]
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La funzione vocale è limitata a 100 caratteri
Opzioni : Cronologia : Aiuto : OpinioniChiudere
[h=1]The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice.[/h] Warfield KL[SUP]1[/SUP], Barnard DL[SUP]2[/SUP], Enterlein SG[SUP]3[/SUP], Smee DF[SUP]4[/SUP], Khaliq M[SUP]1[/SUP], Sampath A[SUP]5[/SUP], Callahan MV[SUP]6,[/SUP][SUP]7[/SUP], Ramstedt U[SUP]8[/SUP], Day CW[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned.
[h=4]KEYWORDS:[/h] Iminosugar; UV-4B; antiviral; human bronchial epithelial cells; influenza; mice
PMID: 27072420 [PubMed - in process] PMCID: PMC4810261 Free full text
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[TD="width: 10%, align: right"][/TD]
[TD="width: 20%, align: left"]Rileva linguaAfrikaansAlbaneseAraboArmenoAzeroBascoBengaleseBielorussoBirmanoBosniacoBulgaroCatalanoCebuanoCecoChichewaCinese (semp)Cinese (trad)CoreanoCreolo HaitianoCroatoDaneseEbraicoEsperantoEstoneFilippinoFinlandeseFranceseGalizianoGalleseGeorgianoGiapponeseGiavaneseGrecoGujaratiHausaHindiHmongIgboIndonesianoIngleseIrlandeseIslandeseItalianoKannadaKazakoKhmerLaoLatinoLettoneLituanoMacedoneMalabareseMalagasyMaleseMalteseMaoriMaratiMongoloNepaleseNorvegeseOlandesePersianoPolaccoPortoghesePunjabiRumenoRussoSerboSesothoSingaleseSlovaccoSlovenoSomaloSpagnoloSundaneseSvedeseSwahiliTagikoTailandeseTamilTedescoTeluguTurcoUcrainoUnghereseUrduUsbecoVietnamitaYiddishYorubaZulu[/TD]
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[/TD][TD="width: 20%, align: left"]AfrikaansAlbaneseAraboArmenoAzeroBascoBengaleseBielorussoBirmanoBosniacoBulgaroCatalanoCebuanoCecoChichewaCinese (semp)Cinese (trad)CoreanoCreolo HaitianoCroatoDaneseEbraicoEsperantoEstoneFilippinoFinlandeseFranceseGalizianoGalleseGeorgianoGiapponeseGiavaneseGrecoGujaratiHausaHindiHmongIgboIndonesianoIngleseIrlandeseIslandeseItalianoKannadaKazakoKhmerLaoLatinoLettoneLituanoMacedoneMalabareseMalagasyMaleseMalteseMaoriMaratiMongoloNepaleseNorvegeseOlandesePersianoPolaccoPortoghesePunjabiRumenoRussoSerboSesothoSingaleseSlovaccoSlovenoSomaloSpagnoloSundaneseSvedeseSwahiliTagikoTailandeseTamilTedescoTeluguTurcoUcrainoUnghereseUrduUsbecoVietnamitaYiddishYorubaZulu[/TD]
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La funzione vocale è limitata a 100 caratteri
Opzioni : Cronologia : Aiuto : OpinioniChiudere