tetano
Editor, Senior Moderator
J Virol. 2013 Sep 18. [Epub ahead of print]
The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm.
Xiao H, Killip MJ, Staeheli P, Randall RE, Jackson D.
Source
Biomolecular Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST, United Kingdom.
Abstract
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
PMID:
24049170
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24049170
The human interferon-induced MxA protein inhibits early stages of influenza A virus infection by retaining the incoming viral genome in the cytoplasm.
Xiao H, Killip MJ, Staeheli P, Randall RE, Jackson D.
Source
Biomolecular Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, KY16 9ST, United Kingdom.
Abstract
The induction of an interferon-induced antiviral state is a powerful cellular response against viral infection that limits viral spread. Here we show that a pre-existing antiviral state inhibits replication of influenza A viruses in human A549 cells by preventing transport of the viral genome to the nucleus and the interferon-induced MxA protein is necessary but not sufficient for this process. This represents a previously unreported antiviral function of MxA against influenza A virus infection.
PMID:
24049170
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24049170