tetano
Editor, Senior Moderator
Antimicrob Agents Chemother. 2012 Aug 20. [Epub ahead of print]
The Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses.
Muratore G, Mercorelli B, Goracci L, Cruciani G, Digard P, Pal? G, Loregian A.
Source
Department of Molecular Medicine, University of Padua, Padua, Italy.
Abstract
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
PMID:
22908168
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22908168
The Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses.
Muratore G, Mercorelli B, Goracci L, Cruciani G, Digard P, Pal? G, Loregian A.
Source
Department of Molecular Medicine, University of Padua, Padua, Italy.
Abstract
AL18, an inhibitor of human cytomegalovirus DNA polymerase, was serendipitously found to also block the interaction between the PB1 and PA polymerase subunits of influenza A virus. Furthermore, AL18 effectively inhibited influenza A virus polymerase activity and the overall replication of influenza A and B viruses. A molecular model to explain the binding of AL18 to both cytomegalovirus and influenza targets is proposed. Thus, AL18 represents an interesting lead for the development of new antivirals.
PMID:
22908168
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22908168