tetano
Editor, Senior Moderator
J Gen Virol. 2012 Aug 15. [Epub ahead of print]
The fate of influenza A virus after infection of human macrophages and dendritic cells.
Short KR, Brooks AG, Reading PC, Londrigan SL.
Source
The Department of Microbiology and Immunology, The University of Melbourne;
Abstract
Airway macrophages (MΦ) and dendritic cells (DC) are important components of innate host defense. Historically, these immune cells have been considered to play a critical role in controlling the severity of influenza A virus (IAV) infection by limiting virus release, initiating local inflammatory responses and by eliciting priming for subsequent adaptive immune responses. However, some IAV strains have been reported to replicate productively in human immune cells. Potential amplification and dissemination of IAV from immune cells may therefore be an important virulence determinant. Herein, we will review findings in relation to the fate of IAV following infection of MΦ and DC. Insights regarding the consequences and outcomes of IAV infection of airway MΦ and DC are discussed in order to gain a better understanding of the pathogenesis of influenza virus.
PMID:
22894921
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22894921
The fate of influenza A virus after infection of human macrophages and dendritic cells.
Short KR, Brooks AG, Reading PC, Londrigan SL.
Source
The Department of Microbiology and Immunology, The University of Melbourne;
Abstract
Airway macrophages (MΦ) and dendritic cells (DC) are important components of innate host defense. Historically, these immune cells have been considered to play a critical role in controlling the severity of influenza A virus (IAV) infection by limiting virus release, initiating local inflammatory responses and by eliciting priming for subsequent adaptive immune responses. However, some IAV strains have been reported to replicate productively in human immune cells. Potential amplification and dissemination of IAV from immune cells may therefore be an important virulence determinant. Herein, we will review findings in relation to the fate of IAV following infection of MΦ and DC. Insights regarding the consequences and outcomes of IAV infection of airway MΦ and DC are discussed in order to gain a better understanding of the pathogenesis of influenza virus.
PMID:
22894921
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22894921