tetano
Editor, Senior Moderator
Chem Commun (Camb). 2013 Jan 31. [Epub ahead of print]
The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action.
Naumov P, Yasuda N, Rabeh WM, Bernstein J.
Source
New York University Abu Dhabi, PO Box 129188, Abu Dhabi, UAE. pance.naumov@nyu.edu.
Abstract
The first structure determination of a neuraminidase inhibitor, oseltamivir phosphate, the active component of the anti-influenza agent Tamiflu, was achieved by single crystal X-ray diffraction with synchrotron radiation. The structure reproduces to a great extent the binding of the inhibitor in the neuraminidase active site and provides more accurate structural parameters as well as detailed insight into the binding preferences of the inhibitor.
PMID:
23370708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23370708
The elusive crystal structure of the neuraminidase inhibitor Tamiflu (oseltamivir phosphate): molecular details of action.
Naumov P, Yasuda N, Rabeh WM, Bernstein J.
Source
New York University Abu Dhabi, PO Box 129188, Abu Dhabi, UAE. pance.naumov@nyu.edu.
Abstract
The first structure determination of a neuraminidase inhibitor, oseltamivir phosphate, the active component of the anti-influenza agent Tamiflu, was achieved by single crystal X-ray diffraction with synchrotron radiation. The structure reproduces to a great extent the binding of the inhibitor in the neuraminidase active site and provides more accurate structural parameters as well as detailed insight into the binding preferences of the inhibitor.
PMID:
23370708
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23370708