tetano
Editor, Senior Moderator
PLoS One. 2019 Apr 15;14(4):e0215321. doi: 10.1371/journal.pone.0215321. eCollection 2019.
[h=1]The effect of respiratory viruses on immunogenicity and protection induced by a candidate universal influenza vaccine in mice.[/h] Rowell J[SUP]1[/SUP], Lo CY[SUP]1[/SUP], Price GE[SUP]1[/SUP], Misplon JA[SUP]1[/SUP], Crim RL[SUP]2[/SUP], Jayanti P[SUP]2[/SUP], Beeler J[SUP]2[/SUP], Epstein SL[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Current approaches to influenza control rely on vaccines matched to viruses in circulation. Universal influenza vaccines would offer the advantage of providing broad protection against diverse strains of influenza virus. Candidate universal vaccines are developed using model systems, often testing in na?ve animals. Yet the human population is not na?ve, having varied immune histories that include exposure to viruses. We studied a candidate universal influenza vaccine (replication deficient adenoviruses expressing the conserved influenza A antigens NP and M2 [A/NP+M2-rAd]) given intranasally, the route previously shown to be most effective. To model recipients exposed to viruses, we used mice given rhinovirus (RV1B), respiratory syncytial virus (RSV-A2), influenza B virus, or influenza A virus before or after universal influenza vaccine. Vaccine performance was assessed by measuring immune responses to NP and M2, and monitoring weight loss and survival following influenza A challenge. Prior influenza A virus infection enhanced the response to the vaccine by priming to conserved influenza A antigens. RSV-A2 or RV1B had no effect on antibody responses to NP and M2 in serum. None of the viruses inhibited the ability of the vaccine to protect against influenza A virus challenge. The study demonstrates that the usefulness of this universal vaccine is not confined to the immunologically na?ve and supports possible use in a human population with a varied history of respiratory infections.
PMID: 30986224 DOI: 10.1371/journal.pone.0215321
Free full text
[h=1]The effect of respiratory viruses on immunogenicity and protection induced by a candidate universal influenza vaccine in mice.[/h] Rowell J[SUP]1[/SUP], Lo CY[SUP]1[/SUP], Price GE[SUP]1[/SUP], Misplon JA[SUP]1[/SUP], Crim RL[SUP]2[/SUP], Jayanti P[SUP]2[/SUP], Beeler J[SUP]2[/SUP], Epstein SL[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Current approaches to influenza control rely on vaccines matched to viruses in circulation. Universal influenza vaccines would offer the advantage of providing broad protection against diverse strains of influenza virus. Candidate universal vaccines are developed using model systems, often testing in na?ve animals. Yet the human population is not na?ve, having varied immune histories that include exposure to viruses. We studied a candidate universal influenza vaccine (replication deficient adenoviruses expressing the conserved influenza A antigens NP and M2 [A/NP+M2-rAd]) given intranasally, the route previously shown to be most effective. To model recipients exposed to viruses, we used mice given rhinovirus (RV1B), respiratory syncytial virus (RSV-A2), influenza B virus, or influenza A virus before or after universal influenza vaccine. Vaccine performance was assessed by measuring immune responses to NP and M2, and monitoring weight loss and survival following influenza A challenge. Prior influenza A virus infection enhanced the response to the vaccine by priming to conserved influenza A antigens. RSV-A2 or RV1B had no effect on antibody responses to NP and M2 in serum. None of the viruses inhibited the ability of the vaccine to protect against influenza A virus challenge. The study demonstrates that the usefulness of this universal vaccine is not confined to the immunologically na?ve and supports possible use in a human population with a varied history of respiratory infections.
PMID: 30986224 DOI: 10.1371/journal.pone.0215321
Free full text