tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2012 Dec 17. [Epub ahead of print]
The Effect of Exclusive Breastfeeding on Respiratory Illness in Young Infants in a Maternal Immunization Trial in Bangladesh.
Henkle E, Steinhoff MC, Omer SB, Roy E, Arifeen SE, Raqib R, Breiman RF, Caulfield LE, Moss WJ, Zaman K.
Source
1Center for Health Research-Northwest, Kaiser Permanente, Portland, OR, USA 2Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA 4Rollins School of Public Health, Emory University, Atlanta, GA, USA 5Center for Health Research-Southeast, Kaiser Permanente, Atlanta, GA, USA 6ICDDR,B, Dhaka, Bangladesh.
Abstract
BACKGROUND:: Exclusive breastfeeding reduces the risk of respiratory illness in infants younger than 6 months of age in developing countries by approximately half. We evaluated the effect of exclusive breastfeeding on respiratory illness with fever (RIF) in Bangladeshi infants in the context of a randomized maternal influenza immunization trial. METHODS:: Infants in a maternal vaccine trial in Dhaka, Bangladesh were prospectively assessed at weekly intervals for 6 months after birth for breastfeeding practices and RIF. We estimated the risk of a RIF episode for infants who were exclusively breastfed the prior week compared with infants not exclusively breastfed the prior week using generalized estimating equations. RESULTS:: We followed a total of 331 infants from birth to 24 weeks of age. The median weeks infants were exclusively breastfed was 15 (IQR 6-21). The adjusted independent odds of respiratory illness for exclusively breastfed infants compared with non-exclusively breastfed infants was 0.59 (95% CI 0.45-0.77) for a RIF episode. After adjusting for exclusive breastfeeding, we confirmed the previous report that maternal immunization with influenza vaccine had an independent protective effect against RIF (OR 0.72, 95% CI 0.55-0.93). No significant difference in the protective effect of exclusive breastfeeding was seen by maternal influenza immunization status. CONCLUSIONS:: Exclusive breastfeeding during the first 6 months of life and maternal immunization with influenza vaccine independently and substantially reduced respiratory illness with fever in infants.
PMID:
23249922
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23249922
The Effect of Exclusive Breastfeeding on Respiratory Illness in Young Infants in a Maternal Immunization Trial in Bangladesh.
Henkle E, Steinhoff MC, Omer SB, Roy E, Arifeen SE, Raqib R, Breiman RF, Caulfield LE, Moss WJ, Zaman K.
Source
1Center for Health Research-Northwest, Kaiser Permanente, Portland, OR, USA 2Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA 4Rollins School of Public Health, Emory University, Atlanta, GA, USA 5Center for Health Research-Southeast, Kaiser Permanente, Atlanta, GA, USA 6ICDDR,B, Dhaka, Bangladesh.
Abstract
BACKGROUND:: Exclusive breastfeeding reduces the risk of respiratory illness in infants younger than 6 months of age in developing countries by approximately half. We evaluated the effect of exclusive breastfeeding on respiratory illness with fever (RIF) in Bangladeshi infants in the context of a randomized maternal influenza immunization trial. METHODS:: Infants in a maternal vaccine trial in Dhaka, Bangladesh were prospectively assessed at weekly intervals for 6 months after birth for breastfeeding practices and RIF. We estimated the risk of a RIF episode for infants who were exclusively breastfed the prior week compared with infants not exclusively breastfed the prior week using generalized estimating equations. RESULTS:: We followed a total of 331 infants from birth to 24 weeks of age. The median weeks infants were exclusively breastfed was 15 (IQR 6-21). The adjusted independent odds of respiratory illness for exclusively breastfed infants compared with non-exclusively breastfed infants was 0.59 (95% CI 0.45-0.77) for a RIF episode. After adjusting for exclusive breastfeeding, we confirmed the previous report that maternal immunization with influenza vaccine had an independent protective effect against RIF (OR 0.72, 95% CI 0.55-0.93). No significant difference in the protective effect of exclusive breastfeeding was seen by maternal influenza immunization status. CONCLUSIONS:: Exclusive breastfeeding during the first 6 months of life and maternal immunization with influenza vaccine independently and substantially reduced respiratory illness with fever in infants.
PMID:
23249922
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23249922