tetano
Editor, Senior Moderator
Clin Respir J. 2015 Oct 31. doi: 10.1111/crj.12409. [Epub ahead of print]
[h=1]The duration of cough in patients with H1N1 influenza.[/h] Lin L[SUP]1,[/SUP][SUP]2[/SUP], Yang ZF[SUP]1[/SUP], Zhan YQ[SUP]1[/SUP], Luo W[SUP]1[/SUP], Liu BJ[SUP]1[/SUP], Pan JY[SUP]1[/SUP], Yi F[SUP]1[/SUP], Chen RC[SUP]1[/SUP], Lai KF[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Cough is one of common symptoms of influenza, the cough duration and prevalence of postinfectious cough after viral upper respiratory tract infection has not been well described.
[h=4]OBJECTIVES:[/h] We aim to investigate the duration of cough and prevalence of postinfectious cough (PIC) and its relation with acute symptoms, airway inflammation, and cough sensitivity in patients with H1N1 influenza.
[h=4]METHODS:[/h] Patients with acute symptoms of H1N1 influenza were enrolled and followed up until cough relived. Spirometry, induced sputum test, capsaicin challenge test were conducted in patients with PIC. Cough sensitivity was presented as logarithm of provocative concentration inducing 5 or more coughs (logC5) Results: A total of 141 cases with H1N1 influenza were enrolled. In patients with H1N1 influenza, 97.2% of them complained cough. The duration of cough was as following: <1 week (73.0%); 1-2 weeks (7.8%); 2-3 weeks (7.8%); ≥3 weeks(8.5%). Twelve (8.5%) patients had cough lasting more than 3 weeks (postinfectious cough), 4(2.8%) patients developed chronic cough (>8 weeks). Acute symptoms, spirometry, bronchial responsiveness and sputum differential cell count were similar between patients with PIC and those without PIC, however, there was a higher prevalence of previous PIC (58.3% vs 14.7%, p<0.05) and elevated cough sensitivity (lgC5: 1.18?0.58 vs 2.73?0.33, p<0.01) in patients with PIC as compared with the patients without PIC.
[h=4]CONCLUSIONS:[/h] Acute cough is common in patients with H1N1 postinfectious cough, only a few of patients develop chronic cough. Acute symptoms cannot predict postinfectious cough. which is related with previous postinfectious cough and increased cough sensitivity. This article is protected by copyright. All rights reserved.
Copyright ? 2015 John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] Cough sensitivity; Influenza; Post infectious cough; ： Cough
PMID: 26519198 [PubMed - as supplied by publisher]
[h=1]The duration of cough in patients with H1N1 influenza.[/h] Lin L[SUP]1,[/SUP][SUP]2[/SUP], Yang ZF[SUP]1[/SUP], Zhan YQ[SUP]1[/SUP], Luo W[SUP]1[/SUP], Liu BJ[SUP]1[/SUP], Pan JY[SUP]1[/SUP], Yi F[SUP]1[/SUP], Chen RC[SUP]1[/SUP], Lai KF[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Cough is one of common symptoms of influenza, the cough duration and prevalence of postinfectious cough after viral upper respiratory tract infection has not been well described.
[h=4]OBJECTIVES:[/h] We aim to investigate the duration of cough and prevalence of postinfectious cough (PIC) and its relation with acute symptoms, airway inflammation, and cough sensitivity in patients with H1N1 influenza.
[h=4]METHODS:[/h] Patients with acute symptoms of H1N1 influenza were enrolled and followed up until cough relived. Spirometry, induced sputum test, capsaicin challenge test were conducted in patients with PIC. Cough sensitivity was presented as logarithm of provocative concentration inducing 5 or more coughs (logC5) Results: A total of 141 cases with H1N1 influenza were enrolled. In patients with H1N1 influenza, 97.2% of them complained cough. The duration of cough was as following: <1 week (73.0%); 1-2 weeks (7.8%); 2-3 weeks (7.8%); ≥3 weeks(8.5%). Twelve (8.5%) patients had cough lasting more than 3 weeks (postinfectious cough), 4(2.8%) patients developed chronic cough (>8 weeks). Acute symptoms, spirometry, bronchial responsiveness and sputum differential cell count were similar between patients with PIC and those without PIC, however, there was a higher prevalence of previous PIC (58.3% vs 14.7%, p<0.05) and elevated cough sensitivity (lgC5: 1.18?0.58 vs 2.73?0.33, p<0.01) in patients with PIC as compared with the patients without PIC.
[h=4]CONCLUSIONS:[/h] Acute cough is common in patients with H1N1 postinfectious cough, only a few of patients develop chronic cough. Acute symptoms cannot predict postinfectious cough. which is related with previous postinfectious cough and increased cough sensitivity. This article is protected by copyright. All rights reserved.
Copyright ? 2015 John Wiley & Sons Ltd.
[h=4]KEYWORDS:[/h] Cough sensitivity; Influenza; Post infectious cough; ： Cough
PMID: 26519198 [PubMed - as supplied by publisher]