tetano
Editor, Senior Moderator
Vaccine. 2011 Nov 24. [Epub ahead of print]
The association of seasonal influenza vaccination with pandemic influenza H1N1 2009 infection.
Kelly H, Mercer G, Cowling BJ.
Source
Epidemiology Unit, Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street North, Melbourne, Victoria 3051, Australia.
Abstract
In 2010 Skowronski and colleagues reported that seasonal influenza vaccine appeared to increase the risk of pandemic influenza H1N1 2009 (pH1N1) infection during the first pandemic wave in Canada [1]. They suggested a number of possible explanations for their unexpected finding: firstly, that the results were an artefact of selection bias or confounding; secondly, that the results were due to partial mediation through a biological mechanism; and thirdly, that the results were due to a direct immune mechanism, such as antibody dependent enhancement [1]. In a recent paper in Vaccine, Rosella and colleagues have investigated in detail the first of these possibilities, confirming that it is unlikely an unidentified confounder could have explained the findings [2].
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
22119923
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22119923
The association of seasonal influenza vaccination with pandemic influenza H1N1 2009 infection.
Kelly H, Mercer G, Cowling BJ.
Source
Epidemiology Unit, Victorian Infectious Diseases Reference Laboratory, 10 Wreckyn Street North, Melbourne, Victoria 3051, Australia.
Abstract
In 2010 Skowronski and colleagues reported that seasonal influenza vaccine appeared to increase the risk of pandemic influenza H1N1 2009 (pH1N1) infection during the first pandemic wave in Canada [1]. They suggested a number of possible explanations for their unexpected finding: firstly, that the results were an artefact of selection bias or confounding; secondly, that the results were due to partial mediation through a biological mechanism; and thirdly, that the results were due to a direct immune mechanism, such as antibody dependent enhancement [1]. In a recent paper in Vaccine, Rosella and colleagues have investigated in detail the first of these possibilities, confirming that it is unlikely an unidentified confounder could have explained the findings [2].
Copyright ? 2011. Published by Elsevier Ltd.
PMID:
22119923
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22119923