tetano
Editor, Senior Moderator
Respir Care. 2018 Oct 30. pii: respcare.06145. doi: 10.4187/respcare.06145. [Epub ahead of print]
[h=1]The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis.[/h] Insel M[SUP]1[/SUP], Natt B[SUP]2[/SUP], Mosier J[SUP]3[/SUP], Malo J[SUP]2[/SUP], Bime C[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The 2009 H1N1 influenza epidemic saw a rise in the use of extracorporeal membrane oxygenation (ECMO) as a supportive therapy for refractory ARDS. We sought to determine whether ECMO utilization follows a seasonal pattern that matches the influenza season, and whether it can further be explained by the incidence of each influenza subtype.
[h=4]METHODS:[/h] We performed a longitudinal analysis of non-cardiac and cardiac-associated ECMO cases from the National In-patient Sample from 2005 to 2014, using overdispersed Poisson regression to evaluate associations with influenza incidence categorized by influenza-like illness and total positive influenza tests divided by subtype from the Centers for Disease Control and Prevention.
[h=4]RESULTS:[/h] Non-cardiac ECMO use was positively associated with influenza-like illness incidence in the current month (incidence risk ratio [IRR] 1.11, 95% confidence interval [CI] 1.07-1.15, P < .001) and with influenza-like illness in the previous month (IRR 1.09, 95% CI 1.05-1.14, P < .001). The 2009 H1N1 subtype had the strongest association with non-cardiac ECMO (IRR 1.19, 95% CI 1.09-1.31, P < .001). Cardiac ECMO was also positively associated with the incidence of influenza-like illness (IRR 1.05, 95% CI 1.01-1.09, P = .02).
[h=4]CONCLUSION:[/h] Non-cardiac and cardiac ECMO use in the United States were significantly associated with influenza incidence. The influenza A, H1N1 2009, subtype had the strongest association.
Copyright ? 2018 by Daedalus Enterprises.
[h=4]KEYWORDS:[/h] ECMO; H1N1 virus; acute respiratory distress syndrome; adults; epidemiology; influenza virus
PMID: 30377246 DOI: 10.4187/respcare.06145
[h=1]The Association of Non-Cardiac ECMO With Influenza Incidence: A Time Series Analysis.[/h] Insel M[SUP]1[/SUP], Natt B[SUP]2[/SUP], Mosier J[SUP]3[/SUP], Malo J[SUP]2[/SUP], Bime C[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The 2009 H1N1 influenza epidemic saw a rise in the use of extracorporeal membrane oxygenation (ECMO) as a supportive therapy for refractory ARDS. We sought to determine whether ECMO utilization follows a seasonal pattern that matches the influenza season, and whether it can further be explained by the incidence of each influenza subtype.
[h=4]METHODS:[/h] We performed a longitudinal analysis of non-cardiac and cardiac-associated ECMO cases from the National In-patient Sample from 2005 to 2014, using overdispersed Poisson regression to evaluate associations with influenza incidence categorized by influenza-like illness and total positive influenza tests divided by subtype from the Centers for Disease Control and Prevention.
[h=4]RESULTS:[/h] Non-cardiac ECMO use was positively associated with influenza-like illness incidence in the current month (incidence risk ratio [IRR] 1.11, 95% confidence interval [CI] 1.07-1.15, P < .001) and with influenza-like illness in the previous month (IRR 1.09, 95% CI 1.05-1.14, P < .001). The 2009 H1N1 subtype had the strongest association with non-cardiac ECMO (IRR 1.19, 95% CI 1.09-1.31, P < .001). Cardiac ECMO was also positively associated with the incidence of influenza-like illness (IRR 1.05, 95% CI 1.01-1.09, P = .02).
[h=4]CONCLUSION:[/h] Non-cardiac and cardiac ECMO use in the United States were significantly associated with influenza incidence. The influenza A, H1N1 2009, subtype had the strongest association.
Copyright ? 2018 by Daedalus Enterprises.
[h=4]KEYWORDS:[/h] ECMO; H1N1 virus; acute respiratory distress syndrome; adults; epidemiology; influenza virus
PMID: 30377246 DOI: 10.4187/respcare.06145