tetano
Editor, Senior Moderator
J Clin Lab Anal. 2019 Aug 16:e22995. doi: 10.1002/jcla.22995. [Epub ahead of print]
[h=1]The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children.[/h] Fei Y[SUP]1[/SUP], Zhang H[SUP]1[/SUP], Zhang C[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] To explore the characteristics and regularity of complete blood count (CBC) changes among influenza A-positive child patients and to discover parameters that can help with the diagnosis and differential diagnosis.
[h=4]METHODS:[/h] One hundred and ninety-one influenza A-positive children, two hundred and nineteen influenza A-negative children with influenza-like symptoms, and two hundred and forty-seven healthy children were included in this study. They were divided into three groups: influenza A-positive patient group, influenza A-negative patient group, and control group. Reverse transcriptase polymerase chain reaction testing and Sysmex XS-800i hematology analyzer were used to obtain influenza A and CBC results, respectively. CBC along with parameters including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPV/PLT), and lymphocyte*platelet (LYM*PLT) was calculated and recorded for each child. The differences in these parameters among different groups were tested with SPSS 15.0. The diagnostic values were also evaluated.
[h=4]RESULTS:[/h] The LYM and PLT of child patients with influenza A were significantly lower than those of both influenza A-negative patients with influenza-like symptoms and healthy controls. Among all the parameters, LYM*PLT has the largest area under the curve and the highest diagnostic value, followed by MPV/PLT. Compared with using LMR or MPV/PLT, the diagnostic value of using LYM alone was, on the contrary, higher.
[h=4]CONCLUSIONS:[/h] Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza-like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection.
? 2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.
[h=4]KEYWORDS:[/h] influenza A; lymphopenia; mean platelet volume; thrombocytopenia
PMID: 31420904 DOI: 10.1002/jcla.22995
[h=1]The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children.[/h] Fei Y[SUP]1[/SUP], Zhang H[SUP]1[/SUP], Zhang C[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] To explore the characteristics and regularity of complete blood count (CBC) changes among influenza A-positive child patients and to discover parameters that can help with the diagnosis and differential diagnosis.
[h=4]METHODS:[/h] One hundred and ninety-one influenza A-positive children, two hundred and nineteen influenza A-negative children with influenza-like symptoms, and two hundred and forty-seven healthy children were included in this study. They were divided into three groups: influenza A-positive patient group, influenza A-negative patient group, and control group. Reverse transcriptase polymerase chain reaction testing and Sysmex XS-800i hematology analyzer were used to obtain influenza A and CBC results, respectively. CBC along with parameters including lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume/platelet ratio (MPV/PLT), and lymphocyte*platelet (LYM*PLT) was calculated and recorded for each child. The differences in these parameters among different groups were tested with SPSS 15.0. The diagnostic values were also evaluated.
[h=4]RESULTS:[/h] The LYM and PLT of child patients with influenza A were significantly lower than those of both influenza A-negative patients with influenza-like symptoms and healthy controls. Among all the parameters, LYM*PLT has the largest area under the curve and the highest diagnostic value, followed by MPV/PLT. Compared with using LMR or MPV/PLT, the diagnostic value of using LYM alone was, on the contrary, higher.
[h=4]CONCLUSIONS:[/h] Low LYM*PLT and high MPV/PLT may indicate influenza A infection in children with influenza-like symptoms, which can be a useful indicator for diagnosis and differentiation of influenza A infection.
? 2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.
[h=4]KEYWORDS:[/h] influenza A; lymphopenia; mean platelet volume; thrombocytopenia
PMID: 31420904 DOI: 10.1002/jcla.22995