tetano
Editor, Senior Moderator
Viruses. 2019 Apr 30;11(5). pii: E405. doi: 10.3390/v11050405.
[h=1]Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus.[/h] Zhang Y[SUP]1[/SUP], Xu C[SUP]2[/SUP], Zhang H[SUP]3[/SUP], Liu GD[SUP]4[/SUP], Xue C[SUP]5[/SUP], Cao Y[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A viruses are dynamically epidemic and genetically diverse. Due to the antigenic drift and shift of the virus, seasonal vaccines are required to be reformulated annually to match with current circulating strains. However, the mismatch between vaccinal strains and circulating strains occurs frequently, resulting in the low efficacy of seasonal vaccines. Therefore, several "universal" vaccine candidates based on the structure and function of the hemagglutinin (HA) protein have been developed to meet the requirement of a broad protection against homo-/heterosubtypic challenges. Here, we review recent novel constructs and discuss several important findings regarding the broad protective efficacy of HA-based universal vaccines.
[h=4]KEYWORDS:[/h] hemagglutinin; influenza A virus; universal influenza vaccine
PMID: 31052339 DOI: 10.3390/v11050405
Free full text
[h=1]Targeting Hemagglutinin: Approaches for Broad Protection against the Influenza A Virus.[/h] Zhang Y[SUP]1[/SUP], Xu C[SUP]2[/SUP], Zhang H[SUP]3[/SUP], Liu GD[SUP]4[/SUP], Xue C[SUP]5[/SUP], Cao Y[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza A viruses are dynamically epidemic and genetically diverse. Due to the antigenic drift and shift of the virus, seasonal vaccines are required to be reformulated annually to match with current circulating strains. However, the mismatch between vaccinal strains and circulating strains occurs frequently, resulting in the low efficacy of seasonal vaccines. Therefore, several "universal" vaccine candidates based on the structure and function of the hemagglutinin (HA) protein have been developed to meet the requirement of a broad protection against homo-/heterosubtypic challenges. Here, we review recent novel constructs and discuss several important findings regarding the broad protective efficacy of HA-based universal vaccines.
[h=4]KEYWORDS:[/h] hemagglutinin; influenza A virus; universal influenza vaccine
PMID: 31052339 DOI: 10.3390/v11050405
Free full text