tetano
Editor, Senior Moderator
Vaccine. 2015 Aug 24. pii: S0264-410X(15)01157-3. doi: 10.1016/j.vaccine.2015.08.031. [Epub ahead of print]
[h=1]Targeted vaccination in healthy school children - Can primary school vaccination alone control influenza?[/h] Thorrington D[SUP]1[/SUP], Jit M[SUP]2[/SUP], Eames K[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The UK commenced an extension to the seasonal influenza vaccination policy in autumn 2014 that will eventually see all healthy children between the ages of 2-16 years offered annual influenza vaccination. Models suggest that the new policy will be both highly effective at reducing the burden of influenza as well as cost-effective. We explore whether targeting vaccination at either primary or secondary schools would be more effective and/or cost-effective than the current strategy.
[h=4]METHODS:[/h] An age-structured deterministic transmission dynamic SEIR-type mathematical model was used to simulate a national influenza outbreak in England. Costs including GP consultations, hospitalisations due to influenza and vaccinations were compared to potential gains in quality-adjusted life years achieved through vaccinating healthy children. Costs and benefits of the new JCVI vaccination policy were estimated over a single season, and compared to the hypothesised new policies of targeted and heterogeneous vaccination.
[h=4]FINDINGS AND CONCLUSION:[/h] All potential vaccination policies were highly cost-effective. Influenza transmission can be eliminated for a particular season by vaccinating both primary and secondary school children, but not by vaccinating only one group. The most cost-effective policy overall is heterogeneous vaccination coverage with 48% uptake in primary schools and 34% in secondary schools. The Joint Committee on Vaccination and Immunisation can consider a modification to their policy of offering seasonal influenza vaccinations to all healthy children of ages 2-16 years.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Cost-effectiveness analysis; Influenza; Mathematical model; QALYs; Schools; Vaccination
PMID: 26314627 [PubMed - as supplied by publisher]
[h=1]Targeted vaccination in healthy school children - Can primary school vaccination alone control influenza?[/h] Thorrington D[SUP]1[/SUP], Jit M[SUP]2[/SUP], Eames K[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The UK commenced an extension to the seasonal influenza vaccination policy in autumn 2014 that will eventually see all healthy children between the ages of 2-16 years offered annual influenza vaccination. Models suggest that the new policy will be both highly effective at reducing the burden of influenza as well as cost-effective. We explore whether targeting vaccination at either primary or secondary schools would be more effective and/or cost-effective than the current strategy.
[h=4]METHODS:[/h] An age-structured deterministic transmission dynamic SEIR-type mathematical model was used to simulate a national influenza outbreak in England. Costs including GP consultations, hospitalisations due to influenza and vaccinations were compared to potential gains in quality-adjusted life years achieved through vaccinating healthy children. Costs and benefits of the new JCVI vaccination policy were estimated over a single season, and compared to the hypothesised new policies of targeted and heterogeneous vaccination.
[h=4]FINDINGS AND CONCLUSION:[/h] All potential vaccination policies were highly cost-effective. Influenza transmission can be eliminated for a particular season by vaccinating both primary and secondary school children, but not by vaccinating only one group. The most cost-effective policy overall is heterogeneous vaccination coverage with 48% uptake in primary schools and 34% in secondary schools. The Joint Committee on Vaccination and Immunisation can consider a modification to their policy of offering seasonal influenza vaccinations to all healthy children of ages 2-16 years.
Copyright ? 2015. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Cost-effectiveness analysis; Influenza; Mathematical model; QALYs; Schools; Vaccination
PMID: 26314627 [PubMed - as supplied by publisher]