Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

[HenryN]

Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

Over 90% of polymorphisms in 1918 can be found in the two H1N1 viruses (human and swine) from the 1930's (the two 1930's viruses represent what was circulating prior to 1918).

Another HA travel log for Sapporro/1

gb|GQ365446.1| Influenza A virus (A/Sapporo/1/2009(H1N1)) seg... 34.2 2.9
gb|CY040594.1| Influenza A virus (A/swine/North Carolina/4511... 34.2 2.9
gb|CY040543.1| Influenza A virus (A/swine/North Carolina/7386... 34.2 2.9
gb|CY040510.1| Influenza A virus (A/swine/Ohio/63607-32/2008(... 34.2 2.9
gb|CY040509.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040508.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040504.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040503.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040502.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040501.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040500.1| Influenza A virus (A/swine/North Carolina/6360... 34.2 2.9
gb|CY040497.1| Influenza A virus (A/swine/North Carolina/225-... 34.2 2.9
gb|CY040496.1| Influenza A virus (A/swine/North Carolina/225-... 34.2 2.9
gb|CY040495.1| Influenza A virus (A/swine/North Carolina/225-... 34.2 2.9
gb|CY040494.1| Influenza A virus (A/swine/North Carolina/225-... 34.2 2.9
gb|CY040493.1| Influenza A virus (A/swine/Missouri/63607-16/2... 34.2 2.9
gb|CY040490.1| Influenza A virus (A/swine/Minnesota/63607-40/... 34.2 2.9
gb|CY040486.1| Influenza A virus (A/swine/Minnesota/63607-31/... 34.2 2.9
gb|CY040485.1| Influenza A virus (A/swine/Minnesota/63607-30/... 34.2 2.9
gb|CY040483.1| Influenza A virus (A/swine/Minnesota/63607-26/... 34.2 2.9
gb|CY040480.1| Influenza A virus (A/swine/Minnesota/63607-15/... 34.2 2.9
gb|CY040479.1| Influenza A virus (A/swine/Minnesota/63607-12/... 34.2 2.9
gb|CY040477.1| Influenza A virus (A/swine/Minnesota/225-5/200... 34.2 2.9
gb|CY040476.1| Influenza A virus (A/swine/Minnesota/225-4/200... 34.2 2.9
gb|CY040475.1| Influenza A virus (A/swine/Minnesota/225-3/200... 34.2 2.9
gb|CY040471.1| Influenza A virus (A/swine/Iowa/63607-23/2008(... 34.2 2.9
gb|CY040468.1| Influenza A virus (A/swine/Iowa/63607-1/2008 (... 34.2 2.9
gb|CY040466.1| Influenza A virus (A/swine/Iowa/225-8/2008(H1N... 34.2 2.9
gb|CY040461.1| Influenza A virus (A/swine/Illinois/225-1/2008... 34.2 2.9
gb|FJ986621.1| Influenza A virus (A/Ohio/02/2007(H1N1)) segme... 34.2 2.9
gb|FJ986620.1| Influenza A virus (A/Ohio/01/2007(H1N1)) segme... 34.2 2.9
gb|EU604689.1| Influenza A virus (A/swine/OH/511445/2007(H1N1... 34.2 2.9
gb|EU409960.1| Influenza A virus (A/swine/Ohio/C62006/06(H1N1... 34.2 2.9
gb|EU409948.1| Influenza A virus (A/swine/Ohio/24366/07(H1N1)... 34.2 2.9
gb|AY060052.1| Influenza A virus (A/SW/MN/17138/01(H1N2)) hem... 34.2 2.9

 

[HenryN]

Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

The two Ohio human isolates are swine triple reassortants.

 

[Mamabird]

Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

The two Ohio human isolates are swine triple reassortants.

The two Ohio human isolates closely match the Ohio source swine isolate.

Not so with the swine isolates in Alberta, Canada. They do not closely match the human Swine Flu virus H1N1.

It makes one wonder how long the Canadian pig herd had been infected to accumulate that many changes? Probably not a recent human infection being passed on as had been speculated.

 

[Mamabird]

Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

Perhaps we will have a better understanding of just how quickly this pandemic virus changes when a human infects a pig once the Argentina swine isolates are released to the public.

If we do not see changes, especially in the more highly conserved gene segments, then we should revisit the Canadian event.

 

[HenryN]

Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

The two Ohio human isolates closely match the Ohio source swine isolate.

Not so with the swine isolates in Alberta, Canada. They do not closely match the human Swine Flu virus H1N1.

It makes one wonder how long the Canadian pig herd had been infected to accumulate that many changes? Probably not a recent human infection being passed on as had been speculated.

Correct. The swine were not very sick (no fatalities and just a cough) and surveillance (as well as relase of sequences) is/was poor.

 

[Mamabird]

Re: Tamiflu Resistant Pandemic H1N1 Sequence Released (Hong Kong)

The Tamiflu resistant precursor is spreading in Spain. The most recent additions were collected this month (July 3), yet the number of recent sequences (since April) in the US remains at ZERO.
HA sequence hasn't been released, but it likely has D225E.

Catalonia/378 HA (Spain) is actually closer match to Hong Kong Tamiflu resistant strain than Sapporo/1. Has your D225E, plus S206T and P300S.

Italy/172 also has these unique HA markers, but no NA available yet.

Point is, these precursers are circulating widely and must be monitored.