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Tamiflu resistance in seasonal H1N1 - study.

Gert van der Hoek

Gert van der Hoek

In Memoriam - Editor, Senior Moderator
snip from study.


Thorax 2009;64:828; doi:10.1136/thx.2009.126102


Influenza A resistance to oseltamivir

I Ismail

Correspondence to:

Correspondence to Dr I Ismail, CT2, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK; iyad75@hotmail.co.uk


Oseltamivir is a neuraminidase inhibitor used for the treatment and prophylaxis of influenza A infections.

This study investigated the differences in demographics, epidemiology, clinical symptoms, severity of illness and clinical outcomes among patients infected with oseltamivir-resistant or oseltamivir-susceptible influenza A (H1N1) virus in the USA.

Information about viral isolates and their subtypes, particularly H1N1, was collected using data submitted to the Centres for Disease Control and Prevention by US public health laboratories.

Data about illnesses from both groups were collected over the telephone using a standardised questionnaire.

142 out of 1155 cases of influenza A (H1N1) tested were resistant to oseltamivir.

Data were collected from 99 oseltamivir-resistant patients who agreed to participate and 182 oseltamivir-susceptible cases.

Among resistant patients the median age was 19 years; five patients (5%) were hospitalised and four patients (4%) died.

Only the first 150 words of the study could be read.

http://thorax.bmj.com/cgi/content/short/64/9/828?rss=1
 
Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Dutchy said:
snip from study.


Thorax 2009;64:828; doi:10.1136/thx.2009.126102


Influenza A resistance to oseltamivir

I Ismail

Correspondence to:

Correspondence to Dr I Ismail, CT2, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK; iyad75@hotmail.co.uk


Oseltamivir is a neuraminidase inhibitor used for the treatment and prophylaxis of influenza A infections.

This study investigated the differences in demographics, epidemiology, clinical symptoms, severity of illness and clinical outcomes among patients infected with oseltamivir-resistant or oseltamivir-susceptible influenza A (H1N1) virus in the USA.

Information about viral isolates and their subtypes, particularly H1N1, was collected using data submitted to the Centres for Disease Control and Prevention by US public health laboratories.

Data about illnesses from both groups were collected over the telephone using a standardised questionnaire.

142 out of 1155 cases of influenza A (H1N1) tested were resistant to oseltamivir.

Data were collected from 99 oseltamivir-resistant patients who agreed to participate and 182 oseltamivir-susceptible cases.

Among resistant patients the median age was 19 years; five patients (5%) were hospitalised and four patients (4%) died.

Only the first 150 words of the study could be read.

http://thorax.bmj.com/cgi/content/short/64/9/828?rss=1
Click to expand...

I believe this is Seasonal H1N1, not Swine Flu H1N1. If that is the case, then the title probably should reflect such so as not to cause undue alarm.
 
Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Mamabird said:
I believe this is Seasonal H1N1, not Swine Flu H1N1. If that is the case, then the title probably should reflect such so as not to cause undue alarm.
Click to expand...

OK, I'll change it, it was not clear for me, just read : (A) H1N1, so I presumed it was the new H1N1. May be someone who knows more about this can mail to the author? Or check the full study?
 
Re: Tamiflu resistance in seasonal H1N1 - study.

but all seasonal H1N1 (Spainflu) is resistant (100%)
------------------

well, maybe from season 2007/8
 
Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Dutchy said:
OK, I'll change it, it was not clear for me, just read : (A) H1N1, so I presumed it was the new H1N1. May be someone who knows more about this can mail to the author? Or check the full study?
Click to expand...

I agree that (A) H1N1 should be assumed as novel H1N1. A clarification is needed ASAP!
 
Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Re: Tamiflu resistance: 142 samples of 1,155 cases were resistant - study.

Niko said:
I agree that (A) H1N1 should be assumed as novel H1N1. A clarification is needed ASAP!
Click to expand...

You see, this is the type of confusion that is generated when we do not call this pandemic virus by a name that is meaningful. At least the press has not given up on the use of "Swine Flu".

OK, sorry, no more rants today.
 
Re: Tamiflu resistance in seasonal H1N1 - study.

Thank you ironorehopper! Yes, (A) H1N1 and influenza A (H1N1) are not the same :banghead:
 
Re: Tamiflu resistance in seasonal H1N1 - study.

My feeling is: the author and/or the publisher could have done more to prevent confusion.
 
Re: Tamiflu resistance in seasonal H1N1 - study.

Received this mail from the author; I am not sure about the importance of the highlighted sentence.


Dear xxx ,

Thank you for your e-mail. The influenza virus H1N1 in the lung alert is the human version of the virus (Influenza A H1N1 subtype). The novel virus H1N1 is the virus that causes swine flu. So, yes you are right, it is the seasonal H1N1 virus which the study talked about.

One thing to note is that tamiflu or oseltamivir was originally developed against the human (seasonal) H1N1 virus and is now being provisionally used to treat novel H1N1.

Regards

Dr Ismail
 
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