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Tajikistan hit by deadly polio outbreak: WHO

Shiloh

Editor, Senior Moderator
Source: http://www.thenews.com.pk/updates.asp?id=103496

Tajikistan hit by deadly polio outbreak: WHO
Updated at: 1435 PST, Friday, April 23, 2010

GENEVA: The World Health Organisation said Friday that it was investigating a confirmed polio outbreak in Tajikistan which has killed 10 children and marked renewed spread of the disease in central Asia.

A team of WHO experts was sent to the country after local authorities alerted the UN health agency about cases of acute flaccid paralysis detected early this month in southwestern Tajikistan, in an area bordering Afghanistan and Uzbekistan.

"Laboratory tests by the WHO Collaborating Centre in Moscow confirmed polio virus as the cause of the outbreak," the WHO said in a statement.

"WHO immediately alerted all other countries of this new public health risk in Eastern Central Asia, as required under the International Health Regulations."

By April 22, 128 cases of paralysis were reported and 10 of the infected children had died, the agency added.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

I don't understand the red text. Shouldn't children who got the vaccine be immune to the virus?

http://www.who.int/csr/don/2010_04_23/en/index.html

Polio in Tajikistan, first importation since Europe certified polio-free
23 April 2010 -- Poliovirus type 1 has been detected in diagnostic samples from cases of Acute Flaccid Paralysis (AFP) from Tajikistan. This represents the first importation of poliovirus in the WHO European Region since it was certified polio-free in 2002.

As of 21 April 2010, 120 cases of acute flaccid paralysis had been reported from Tajikistan. The majority of these have onset of paralysis within the past 2 weeks, prompting the Government to notify WHO of an outbreak. Ten of the children have died. The vast majority of the cases are children < five years of age. Preliminary data suggests >45% had four or more doses of oral polio vaccine.

To date, poliovirus type 1 has been isolated in diagnostic specimens from 7 of these cases. All cases are in the south-west of the country, in an area bordering Afghanistan and Uzbekistan. Afghanistan is one of the four remaining polio-endemic countries. No cases have been reported in the areas of Afghanistan bordering Tajikistan.

The Government of Tajikistan has requested technical guidance and support from WHO. Vaccine for three outbreak response rounds is being pre-positioned by UNICEF Supply Division for Tajikistan.

Tajikistan's last case of clinically confirmed polio was in 1997; the last case of polio confirmed by virological testing was in 1991. Reported OPV3 coverage nationwide was 87% in 2008, the last year for which complete data are available under the WHO/UNICEF joint reporting process. AFP surveillance indicators in Tajikistan meet certification standards at the national level. In 2009, Tajikistan reported 35 cases of acute flaccid paralysis, of which none were caused by wild poliovirus. Globally, more than 90,000 cases of acute flaccid paralysis were reported in 2009, of which 1606 were caused by wild poliovirus.

Three cases of acute flaccid paralysis have been reported in Uzbekistan on the Tajikistan border; poliovirus has not been isolated yet in laboratory testing. In addition, a child from Tajikistan travelled from Dushanbe to Tashkent for medical treatment shortly after onset of paralysis. The Government of Uzbekistan is planning one nationwide round of vaccination; the Government of Kyrgyzstan, is immunizing children <5 years over the course of European Immunization Week (26-30 April).

WHO is communicating with countries in the Region about the outbreak. It is important that neighboring countries strengthen surveillance for cases of acute flaccid paralysis, in order to rapidly detect any new poliovirus importations and facilitate a rapid response. Countries should also analyze routine immunization coverage data to identify any sub-national gaps in population immunity to guide catch-up immunization activities and thereby minimize the consequences of any new virus introduction. Priority should be given to areas at high-risk of importations and where OPV3/DPT3 coverage is <80%.

This outbreak demonstrates the need to maintain high population immunity until transmission of polio has been interrupted worldwide.

Public health measures such as enhanced surveillance and immunization may be put in place at the borders by Tajik health authorities and their counterparts. It is important that international travellers to and from polio affected areas are adequately immunized against polio as recommended in Chapter 6 of International Travel and Health (see link below).

WHO does not recommend the imposition of restrictions to the international movement of persons as a control measure at this time.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,82388

Archive Number 20100423.1314
Published Date 23-APR-2010
Subject PRO/EDR> Poliomyelitis - Worldwide (03): Tajikistan, RFI


POLIOMYELITIS - WORLDWIDE (03): TAJIKISTAN, REQUEST FOR INFORMATION
*******************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

In this posting:
[1] Subscriber query
[2] Russian language newswire

******
[1] Subscriber query
Date: Thu 22 Apr 2010
From: Mick Mulders <mick.mulders@gmail.com>


Subject: Polio outbreak in Tajikistan
-------------------------------------
Any news about this outbreak? First time since 1998 in polio-free declared
WHO European Region.

--
Dr Mick Mulders
<mick.mulders@gmail.com>

******
[2] Russian language newswire
Date: Thu 22 Apr 2010
Source: RIA (Russian News & Information Agency) Novosti [in Russian,
machine trans., edited]
<http://www.rian.ru/society/20100422/225589803.html>


Russia is ready to help Tajikistan in the fight against the polio outbreak
--------------------------------------------------------------------------
In response to an outbreak of polio reported in Tajikistan, Russia is ready
to help neighbors in the CIS and, if necessary, take protective measures,
the state chief sanitary inspector Dr Gennady Onishchenko told RIA Novosti
on Thursday [22 Apr 2010].

"Today we learned from the World Health Organization (WHO), that there were
more than 100 cases of polio in Tajikistan, including one death. In
addition, they are not localized to one place, but have occurred in several
cities -- for example, in Dushanbe and Leninskiye
-- Onishchenko said.

According to Onishchenko, the 1st cases were registered in Tajikistan in
December 2009, and the Russian Polio Institute helped process specimens
taken from patients. Recently, however, the outbreak has become more
dynamic. [The laboratory testing] has confirmed that the cases are due to
wild poliovirus, not the same strain contained in the polio vaccine, said
Onishchenko
.

"The [occurrence of an] outbreak suggests that the collective ["herd"]
immunity is faltering. Most likely, there were shortcomings in vaccination
[decreases in vaccination coverage
]. We now make the [offer of assistance]
directly to Tajikistan and the CIS and, depending on the outcome, we will
take possible measures to help," he said. According to Onishchenko, Russian
scientists who had experience with outbreaks of polio in India, have
already traveled to Tajikistan
.

"Let us understand what to do in our country. Some quarantine measures
introduced do not have much meaning, but, depending on how events will
unfold, we will take action on its territory," said Onishchenko. "We will
give guidance to our services on the ground that they [should be]
particularly careful when handling citizens of Tajikistan, especially
children," he added.

The head of Rospotrebnadzor [Federal Service for Consumer Affairs and Human
Welfare] was concerned about the situation of poliomyelitis in Tajikistan.
"There has been a breach in the defense, which has practically been formed.
There have been polio outbreaks associated with African countries and
Afghanistan. Now Tajikistan has been added to the list," said Onishchenko.

Poliomyelitis -- an acute infectious disease, children's spinal paralysis,
caused by a lesion of the gray matter of the spinal cord is characterized
mainly by disorders of the nervous system. Introduction of vaccines that
prevent polio, led to rapid reductions in morbidity, and in many areas, the
complete elimination of the disease. For example, Russia since 2002, is a
country free of the virus.

[byline: Alexei Nikolsky]

--
communicated by:
ProMED-mail
<promed@promedmail.org>

[As of Tue 20 Apr 2010, the above mentioned outbreak of polio has not been
reported on the polio eradication website (see
<http://www.polioeradication.org/casecount.asp>). In 2010 to date a total
of 71 cases of polio have been confirmed in the world of which 42 were in
endemic countries [India (19), Pakistan (13), Afghanistan (8), and Nigeria
(2)] and 29 were in non-endemic countries [Senegal (13), Chad (7),
Mauritania (4), Liberia (1), Sierra Leone (1), Angola (1), and Nepal (1)].

From the newswire above, it appears as though there has been significant
wild poliovirus (WPV) transmission in Tajikistan since sometime in December
2009, with the stated "more than 100 cases". (For every paralytic case
identified, there are between 50 and 1000 infected individuals without
paralytic disease, which allows for a somewhat "silent" transmission of the
virus over significant geographic areas).

If the report above is true and not exaggerated, this represents a
significant setback for polio eradication activities in Asia. According to
the WHO website, the last confirmed case of polio in Tajikistan was in
1997, but it was apparently due to a vaccine virus, as there have been no
WPVs confirmed in Tajikistan since 1996 (see
<http://www.who.int/immunization_monitoring/en/diseases/poliomyelitis/afpextract.cfm>).

For a the interactive HealthMap/ProMED map of Tajikistan, see
<http://healthmap.org/r/01dJ>. Tajikistan shares a southern border with
Afghanistan, of which one area is a very narrow strip that separates
Tajikistan from Pakistan -- 2 of the 4 remaining polio endemic countries in
the world. (see <http://www.polioeradication.org>).

ProMED-mail would greatly appreciate more information from knowledgeable
sources on the number of confirmed and probable cases of polio in
Tajikistan, results of genetic testing of the virus identified (wild vs
vaccine derived, type 1, 2, or 3), and genetically confirmed geographic
origin of the virus. - Mod.MPP]
 
Re: Tajikistan hit by deadly polio outbreak: WHO

The red text below might be part of the problem; apparently a monovalent polio vaccine may have been used. Perhaps it wasn't the right strain. The standard vaccine used in much of the world is trivalent (http://www.brown.edu/Courses/Bio_160/Projects1999/polio/vac.html). That link also indicates that the standard trivalent polio vaccine should protect against type 1 poliovirus.

http://translate.googleusercontent....le.com&usg=ALkJrhhYnZxJzYhImWZUi_zvLoHo3eX_Pw

Rospotrebnadzor control of the situation with the possibility of introduction of paralytic polio from Tajikistan.

23.04.2010, Москва 17:37:26 Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека РФ (Роспотребнадзор) контролирует ситуацию с возможностью заноса паралитического полиомиелита из Таджикистана. 23.04.2010, Moscow 17:37:26 The Federal Service for Supervision of Consumer Rights Protection and Human Welfare Federation (Federal Service) control the situation with the possibility of introduction of paralytic polio from Tajikistan. Об этом сообщили в пресс-службе ведомства. This was reported in the press-service agencies.

По данным Министерства здравоохранения Республики Таджикистан, в период с 26 января 2009г. According to the Ministry of Health, in the period from 26 January 2009. по 20 апреля 2010г. April 20, 2010. на территории страны было зарегистрировано 120 случаев острых вялых параличей среди детей в возрасте до 16-ти лет, из них 108 случаев - среди детей в возрасте до 5 лет, 10 случаев заболеваний закончились летальным исходом. in the country recorded 120 cases of acute flaccid paralysis among children under the age of 16 years, of which 108 cases - among children under 5 years, 10 cases resulted in death. Заболевания регистрируются в центральной и юго-западной частях республики. Diseases recorded in the central and southwestern parts of the country. В эпидемический процесс вовлечены 20 территорий страны. The epidemic involved 20 areas of the country.

В Таджикистан выехала группа экспертов для оказания организационно-методической и практической помощи. In Tajikistan has left a group of experts to provide organizational, methodological and practical assistance. Решается вопрос о поставке в страну моновалентной полиовакцины. Solve the question of supply in the country of monovalent polio vaccine.

Роспотребнадзор направил письмо в субъекты РФ о ситуации и принятии первоочередных мер в целях недопущения формирования эпидемических очагов полиомиелита на территории страны. Federal Service sent a letter to the federation's about the situation and taking immediate measures to prevent the emergence of epidemic foci of polio in the country. Также направлено письмо в органы, осуществляющие государственный санитарно-эпидемиологический надзор Таджикистана, о предоставлении информации, связанной с заболеваемостью полиомиелитом и предложением по оказанию практической и методической помощи. Also sent a letter to the authorities exercising state sanitary-epidemiological supervision of Tajikistan, to provide information related to the incidence of polio and the proposal to provide practical and methodological assistance.

В РФ в 2009г. In Russia in 2009. не было зарегистрировано ни одного случая полиомиелита, в том числе вакциноассоциированного. there was no recorded case of polio, including vaktsinoassotsiirovannogo. Это стало возможным благодаря использованию для первичного вакцинального комплекса детям с 3 месяцев только инактивированной полиомиелитной вакцины, пояснили в Роспотребнадзоре. This was made possible through the use of vaccine for the primary set for children from 3 months only inactivated polio vaccine, explained in Rospotrebnadzor.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

Russian doctors say an outbreak of poliomyelitis in Tajikistan and ready to help

04/23/2010 16:24

Author: Asia-Plus


Dushanbe. April 23. "Asia-Plus - Russian authorities to help Tajikistan in combating an outbreak of polio. This, as RIA Novosti reports, chief sanitary doctor Gennady Onishchenko.

According to Onishchenko, cases of infection recorded in several cities of Tajikistan, including in Dushanbe Rudaki. Chapter Rospotrebnadzor noted that the disease is caused by strain of poliovirus, other than that used for the manufacture of vaccines.

The cause of outbreaks of polio in the south-east of Tajikistan Onishchenko called disadvantages of vaccination. "The outbreak suggests that after all collective immunity is faltering", - he explained.

Onishchenko said that Tajikistan had already departed the Russian doctors had previously been involved in the elimination of outbreaks of polio in India. He also noted that Russia has not yet planned to conduct quarantine measures. "Depending on how events will unfold, we will take action on its territory", - added the head of Rospotrebnadzor.

As reported by Russian news agency, a sharp increase in the number of cases of acute flaccid paralysis were reported in Tajikistan in April 2010. As of April 22, the disease was diagnosed in 128 children, 10 of whom died. Seven cases of laboratory confirmed diagnosis of polio. In addition, three cases of acute flaccid paralysis were reported in Uzbekistan.

Meanwhile, as reported by "AP" in the Ministry of Health of Tajikistan on April 22, with the beginning of the year in the country were registered 120 cases of acute flaccid paralysis (AFP). The disease can be caused by poliovirus, but the results of laboratory studies yet.

In the Ministry of Health also noted that to find out why in Tajikistan arrived adviser to WHO. It is expected that upon the recommendation of WHO in the country will be a campaign for polio immunization in conjunction with neighboring countries to prevent the emergence of this disease.

Polio - a disease caused by a virus invades the nervous system, and within a few hours can cause total paralysis. Initial symptoms are fever, fatigue, headache, nausea, stiff neck and pain in the limbs. One in 200 infections leads to irreversible paralysis. The most at risk of contracting the disease are children aged under five years. :tiphat:http://www.asiaplus.tj/news/43/64714.html
 
Re: Tajikistan hit by deadly polio outbreak: WHO

RUSSIA help Tajikistan
Dushanbe, April 23. / NIAT "Howar". - According to the World Health Organization, in Tajikistan, an outbreak of polio. Russia stands ready to assist your partner in the CIS and, if necessary, take protective measures. Told the chief sanitary doctor, Gennady Onishchenko, Russia, AFP reported.

"Today we learned that in Tajikistan with more than 100 polio cases, including death. Moreover, they are not fixed in one place, and in several cities. For example, in Dushanbe and in Rudaki", - said G. Onishchenko.

According to Chief State sanvracha Russia, the first cases were registered in Tajikistan in December last year, and the Russian Institute of polio helped decipher the selected samples from patients. Recently, an outbreak has become more dynamic in nature and for its localization requires urgent action. :tiphat:
http://www.khovar.tj/index.php?option=com_content&task=view&id=20620
 
Re: Tajikistan hit by deadly polio outbreak: WHO

http://en.wikipedia.org/wiki/Polio_vaccine

[snip]

OPV is usually provided in vials containing 10-20 doses of vaccine. A single dose of oral polio vaccine (usually two drops) contains 1,000,000 infectious units of Sabin 1 (effective against PV1), 100,000 infectious units of the Sabin 2 strain, and 600,000 infectious units of Sabin 3. The vaccine contains small traces of antibiotics— neomycin and streptomycin—but does not contain preservatives.[33] One dose of OPV produces immunity to all three poliovirus serotypes in approximately 50% of recipients.[15] Three doses of live-attenuated OPV produce protective antibody to all three poliovirus types in more than 95% of recipients

[snip]

A major concern about the oral polio vaccine (OPV) is its known ability to revert to a form that can achieve neurological infection and cause paralysis.[34] Clinical disease, including paralysis, caused by vaccine-derived poliovirus (VDPV) is indistinguishable from that caused by wild polioviruses.[35] This is believed to be a rare event, but outbreaks of vaccine-associated paralytic poliomyelitis (VAPP) have been reported, and tend to occur in areas of low coverage by OPV, presumably because the OPV is itself protective against the related outbreak strain.[36][37]
 
Re: Tajikistan hit by deadly polio outbreak: WHO

I have heard back from WHO. They are still investigating the situation and have not made any conclusions about what is going on.

Thanks everyone.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

http://www.khabrein.info/news/WHO_deploys_experts_to_face_polio_in_Tajikistan_1272034327/


WHO deploys experts to face polio in Tajikistan

23 April, 2010

GENEVA, April 23 (KUNA) -- The World Health Organization (WHO) said Friday that it has deployed a team of experts to investigate a polio outbreak in the south-west of Tajikistan, in the area bordering Afghanistan and Uzbekistan. Together with its partners at the Global Polio Eradication Initiative, WHO will also support the Tajik Ministry of Health in conducting a mass immunization campaign.




WHO spokesperson Sona Bari said a sharp increase in early April of acute flaccid paralysis cases (AFP) prompted Tajikistan's government to contact WHO about a possible polio outbreak.

She added that as part of a joint investigation by the Tajik national health authorities and WHO, laboratory tests by the WHO Collaborating Centre in Moscow confirmed polio virus as the cause of the outbreak.

Bari added that WHO immediately alerted all other countries of this new public health risk in Eastern Central Asia, as required under the International Health Regulations. and added that this is the first imported polio outbreak in the WHO European Region since the Region was certified polio-free in 2002.

As of 22 April, 128 AFP cases have been reported and 10 of the infected children have died. All cases are in the south-west of the country, in an area bordering Afghanistan and Uzbekistan. Polio virus has been isolated in diagnostic specimens from seven of these cases. Genetic sequencing of the virus is ongoing to further characterize the virus. Uzbekistan has also reported three AFP cases which are under investigation.

Afghanistan, Pakistan, India and Nigeria are the four remaining polio-endemic countries in the world but recent outbreaks were registered in several countries in Africa due to importation. Tajikistan's last case of clinically confirmed polio was in 1997. Reported vaccination coverage nationwide was 87 percent in 2008, which is the last year for which complete data are available to WHO.

This outbreak, however, demonstrates the need to maintain high population immunity until transmission of polio has been interrupted worldwide.

The outbreak coincides with the annual European Immunization Week campaign which begins on 24 April 2010 to raise awareness of vaccine-preventable diseases and the importance of immunization.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

http://en.wikipedia.org/wiki/Polio_vaccine

[snip]

OPV is usually provided in vials containing 10-20 doses of vaccine. A single dose of oral polio vaccine (usually two drops) contains 1,000,000 infectious units of Sabin 1 (effective against PV1), 100,000 infectious units of the Sabin 2 strain, and 600,000 infectious units of Sabin 3. The vaccine contains small traces of antibiotics? neomycin and streptomycin?but does not contain preservatives.[33] One dose of OPV produces immunity to all three poliovirus serotypes in approximately 50% of recipients.[15] Three doses of live-attenuated OPV produce protective antibody to all three poliovirus types in more than 95% of recipients

[snip]

A major concern about the oral polio vaccine (OPV) is its known ability to revert to a form that can achieve neurological infection and cause paralysis.[34] Clinical disease, including paralysis, caused by vaccine-derived poliovirus (VDPV) is indistinguishable from that caused by wild polioviruses.[35] This is believed to be a rare event, but outbreaks of vaccine-associated paralytic poliomyelitis (VAPP) have been reported, and tend to occur in areas of low coverage by OPV, presumably because the OPV is itself protective against the related outbreak strain.[36][37]


Thanks Alert. I do not see "wild type" polio addressed here.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

Thanks Alert. I do not see "wild type" polio addressed here.

"Wild type" is referred to as simply "wild polioviruses" here. Almost all polio is wild type, except those few cases coming from vaccine derived strains.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

Via WHO statement in post #1 -

Preliminary data suggests >45% had four or more doses of oral polio vaccine.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

Via WHO statement in post #1 -

Preliminary data suggests >45% had four or more doses of oral polio vaccine.

And that is what is difficult to explain. Perhaps they had the wrong monovalent vaccine, perhaps those are just the individuals in which the vaccine did not take, or perhaps some of those cases are background noise and not polio (remember only 7 of the 128 cases are confirmed). If the virus really had mutated to evade the vaccine, you would see far more adults ill, and the labs would not easily have confirmed the virus as type 1 wild poliovirus.
 
Re: Tajikistan hit by deadly polio outbreak: WHO

Tajikistan hit by deadly polio outbreak: WHO

<!-- end: .tools -->
<!-- end: .hd --> <CITE class=caption>AFP/File ? World Health Organization headquarters in Geneva. The World Health Organisation said Friday that it was ? </CITE>

<!-- end #main-media -->
<!-- end .primary-media -->
<!-- end .related-media --><ABBR class=recenttimedate title=2010-04-23T09:09:38-0700>20 mins ago</ABBR>
<!-- end .byline -->GENEVA (AFP) ? The World Health Organisation said Friday that it was investigating a confirmed polio outbreak in Tajikistan which has killed 10 children and marked renewed spread of the disease in central Asia.
A team of WHO experts was sent to the country after local authorities alerted the UN health agency about cases of acute flaccid paralysis detected early this month in southwestern Tajikistan, in an area bordering Afghanistan and Uzbekistan.
"Laboratory tests by the WHO Collaborating Centre in Moscow confirmed polio virus as the cause of the outbreak," the WHO said in a statement.
"WHO immediately alerted all other countries of this new public health risk in Eastern Central Asia, as required under the International Health Regulations."
By April 22, 128 cases of paralysis were reported and 10 of the infected children had died, the agency added.
Tajikistan's last case of clinically confirmed polio occurred in 1997.
But the disease is still present in neighbouring Afghanistan, which is one of the four remaining polio endemic countries in the world along with Pakistan, India and Nigeria.
Polio has spread again in recent years with imported cases, especially in Africa, in a setback to global attempts to eradicate the crippling and lethal disease.
WHO said three nationwide vaccination campaigns will be launched shortly in Tajikistan to halt the outbreak.
It also urged nearby Uzbekistan, Turkmenistan, Kyrgyzstan and Kazakhstan to step up polio surveillance and rapidly conduct immunisation campaigns.
The WHO said vaccination coverage in Tajikistan was last estimated at about 87 percent in 2008.
Some 7.6 million children were being immunised last year in Afghanistan, where 38 cases of polio were confirmed in 2009 and another eight so far this year, according to the Global Polio Eradication Initiative.:tiphat:http://news.yahoo.com/s/afp/20100423/hl_afp/healthpoliotajikistanwho_20100423160945
 
Re: Tajikistan hit by deadly polio outbreak: WHO

From the Ukrainian Ministry of Health:

http://www.moz.gov.ua/ua/main/press/?docID=20324

04/23/2010
В Таджикистані 21 квітня 2010 року зареєстровано понад 120 випадків епідемічного паралітичного поліомієліту, у тому 10 випадків ? смертельні, повідомляє Всесвітня організація хорони здоров'я. In Tajikistan, April 21, 2010, more than 120 cases of paralytic polio epidemic, including 10 cases - death, the World Health Organization Keep. Випадки захворювань реєструються з 26 грудня 2009 року у 20 центральних і південно-західних районах Таджикистану, 108 з них - серед дітей у віці до 5 років. Cases registered from 26 December 2009 in 20 central and southwestern parts of Tajikistan, 108 of them - among children under 5 years.

20 квітня 2010 року результати досліджень в референс-лабораторії Європейського регіонального бюро ВООЗ в Інституті поліомієліту і вірусного енцефаліту (Москва, Росія), підтвердили наявність ?дикого? поліовіруса 1 (WPV1) в п'яти зразках, одержаних від хворих. April 20, 2010 research results in the European reference laboratory in the WHO Regional Office for the Institute of Poliomyelitis and Viral Encephalitis (Moscow, Russia), confirmed the presence of wild poliovirusa 1 (WPV1) in five samples obtained from patients.

Для підтримки Міністерства охорони здоров'я Республіки Таджикистан 16 квітня 2010 року ВООЗ направила групу експертів. To support the Ministry of Health of Tajikistan April 16, 2010, WHO sent a team of experts. Наразі в країні проводяться протиепідемічні заходи. Currently in the country are anti-epidemic measures.

Ендемічними з поліомієліту у світі залишається 4 країни (Індія, Пакистан, Афганістан, Нігерія). Endemic polio in the world is still four countries (India, Pakistan, Afghanistan, Nigeria).

Вакцинальна програма щодо поліомієліту забезпечила швидке зниження захворюваності в усьому світі. Vaktsynalna program to ensure rapid decrease in polio incidence in the world. Внаслідок чого багато країн є територіями вільними від поліомієліту. As a result, many countries are polio-free areas.

Україна з 2002 року є вільною від ?дикого? поліовірусу. Ukraine since 2002 is free of "wild" poliovirusu. З 1993 року в Україні не виділявся вірус поліомієліту, а з 1995 року не реєструються випадки захворювання на поліомієліт, викликані "диким" поліовірусом. Since 1993, Ukraine has not stood out polio virus, and in 1995 recorded no cases of polio caused by "wild" poliovirusom.

ДОВІДКА Help

Епідемічний паралітичний поліомієліт - гостре інфекційне захворювання, що може викликати спинномозковий параліч, зумовлений ураженням сірої речовини спинного мозку. Paralytic polio epidemic - acute bacterial disease that can cause spinal paralysis caused by lesion of the spinal cord gray matter. Збудником є ?дикий? вірус поліомієліту. Causing a "wild" polio virus. Джерело інфекції як правило хвора або безсимптомно перехворівша людина. Source of infection is usually asymptomatic or perehvorivsha sick man. Зараження найчастіше відбувається при попаданні в рот активного вірусу через забруднені руки та їжу. Infection often occurs when hit in the mouth of active virus through contaminated hands and food.

Запобігання захворюванню у побуті базується на класичних заходах особистої гігієни - часте миття рук, зміна білизни, застосування дезінфікуючих засобів для прибирання поверхонь, вживання доброякісної їжі та води з дотриманням правил гігієни та інше. Prevention in the home based on classical measures of personal hygiene - frequent hand washing, changing clothes, use disinfectants for cleaning surfaces, the use of safe food and water in compliance with the rules of hygiene and more. Батьки повинні звертати увагу на будь-які зміни у стані здоров'ї дітей. Parents should pay attention to any changes in children's health. Варто перевірити, чи Ви та Ваші діти були щеплені проти поліомієліту. Worth checking out if you and your children were vaccinated against polio.



Прес-служба МОЗ України Press Service of Health of Ukraine
 
Re: Tajikistan hit by deadly polio outbreak: WHO

WHO Investigates Polio Outbreak in Tajikistan

<!-- Removed the byline section from editorials & rewards articles -->Lisa Schlein | Geneva <!-- VOA iNews -->23 April 2010
<!--startclickprintexclude-->http://del.icio.us/post?url=http://...WHO+Investigates+Polio+Outbreak+in+Tajikistan


<!--endclickprintexclude-->The World Health Organization says it is sending technical experts to Tajikistan to investigate an outbreak of seven cases of polio in the country. It says this is the first importation of polio in the European region since Europe was certified as polio-free in 2002.
Three technical experts from WHO already have left for Tajikistan. And, the organization says three more experts are expected to arrive in that central Asian country on Sunday.

WHO Spokeswoman for the Polio Eradication Initiative, Sona Bari, agrees this is a setback for WHO's polio eradication campaign. She says it is a sober reminder of the need to vaccinate children against this crippling disease.

She says the technical experts will carry out a detailed investigation of the seven cases of polio to determine the country from where the virus was imported and what actions need to be taken to prevent its further spread.

"Planning is already going on for three large-scale vaccination campaigns," Bari said. "There are about 864,000 children under the age of five that we will reach with this vaccine. And, surrounding countries, particularly Uzbekistan and Kyrgyztan are being asked to step up their surveillance for acute flaccid paralysis, which is a sign of polio and to look into their immunization rates to make sure that children are adequately protected in those surrounding areas."

Bari says these immunization campaigns are expensive. She says Rotary International has given $500,000. But, additional funding will be needed to buy the vaccines and carry out the campaigns.

She says the polio crisis comes at a time when WHO and other U.N. agencies are struggling to contain a big outbreak in Africa.

"We had a first round to deal with this, this year on the sixth of March, a second smaller round on the 26th of March. And, now, they are starting this Saturday, about 78 million children across central and west Africa to shut down that outbreak," Bari said. "Again, emphasizing the importance of stopping polio in the few remaining endemic countries, so that it cannot be imported out to areas where children are not adequately immunized."

Tajikistan+Curious+Map.jpg


Bari says Tajikistan is close to two polio endemic countries - Afghanistan and Pakistan. But, she says it is premature to identify one of these countries as the source of the virus. She says until the genetic sequencing of the virus is completed, it will not be possible to know from where the importation came.:tiphat:http://www1.voanews.com/english/new...es-Polio-Outbreak-in-Tajikistan-91921054.html
 
Re: Tajikistan hit by deadly polio outbreak: WHO

Polio outbreak in Tajikistan spurs UN vaccination campaign

02-07-who-polio-vacn.jpg
Child being vaccinated against Polio

23 April 2010 ? United Nations health experts have been sent to Tajikistan following a small polio outbreak and planning is under way to vaccinate over 1 million children under five in the impoverished central Asian country, UN officials said today.

The UN Children?s Fund (UNICEF), in cooperation with the Government and its partners, will fly out enough vaccine on Monday to immunize 1.1 million children against the highly infectious ? and sometime fatal but now largely eradicated ? disease that once spread fear among parents worldwide since it mostly targets children.
Global vaccination has now brought polio to the brink of total eradication.
The vaccine is currently in UNICEF?s Copenhagen warehouse and will be delivered in three rounds of immunization, at a cost of $614,000 for the 3.3 million doses, agency spokesperson Christiane Berthiaume told a news briefing in Geneva. Rotary International has contributed $500,000 to the campaign.
The UN World Health Organization (WHO) is waiting for confirmation from Tajik health authorities that seven children have been paralysed, WHO spokesperson Dan Epstein said, adding that the outbreak is significant as it would be the first importation of polio into WHO?s European region, of which Tajikistan is a part, since Europe was certified as polio-free in 2002.

Geographically Tajikistan is close to two polio-endemic countries, Afghanistan and Pakistan, but experience shows that the virus can travel far and geographical proximity is not necessarily the determinant, WHO Polio Eradication Initiative official Sonia Bari said.
Last month, UN agencies and the Afghan health ministry conducted a three-day campaign to vaccinate some 7.7 million children under the age of five against polio.
Three WHO technical experts have already been sent to Tajikistan and three more will arrive on Sunday, while surrounding countries are being asked to step up surveillance for acute flaccid paralysis, a sign of polio, and to look into immunization rates in the surrounding areas to ensure children are adequately protected, Ms. Bari said.

Genetic sequencing is under way to identify the origin of the outbreak, she added, noting that while routine immunization coverage in Tajikistan is around 87 per cent, there are sub-pockets in all countries, including remote rural areas, which are less well vaccinated than others.

In terms of achieving the goal of global eradication in view of these outbreaks, Ms. Bari voiced a sense of optimism, particularly as WHO is witnessing signs of progress never seen before in the world?s four remaining endemic countries ? Afghanistan, India, Nigeria and Pakistan. In Nigeria in particular immense advances have been made; last year at this time Africa?s most populous country had 193 cases; this year it has only two.
Local ownership and management of the anti-polio programme there has brought a sea change, she added, noting that in two polio-endemic states in India, for the first time since records were kept, there had been no new cases of type one polio for the past four months.:tiphat:http://www.un.org/apps/news/story.asp?NewsID=34464&Cr=polio&Cr1=
 
Re: Tajikistan hit by deadly polio outbreak: WHO

This is a ProMED Russian post. The references to 25-50 cases per year are AFP, not necessarily polio. According to this post, there had not been a confirmed polio case in Tajikistan since 2002, before this outbreak.

Also note the 11th AFP death, and the fact that two of them are adults.

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1090,82393

Poliomyelitis (update information) - Tajikistan ******************************************* ******* Date: April 23, 2010 From: ProMED-mail moderator NP Source: IA: "Ca-news", April 23, 2010 [Moderator TM] http://www.ca-news.org/news/ 364851? from = ya In Tajikistan recorded a sharp increase in cases of acute flaccid paralysis. РФ готова оказать помощь ---------------------------------------------------------------------------- CA-NEWS (TJ) - 120 случаев острого вялого паралича зарегистрировано в Таджикистане с начала этого года, сообщает министерство здравоохранения республики, подчеркивая, что ?большинство больных уже вылечено?. По данным министерства, в течение последних восьми лет в стране ежегодно регистрировалось 25-40 случаев этого заболевания. Russia ready to assist ---------------------------------------------- ------------------------------ CA-NEWS (TJ) - 120 cases of acute flaccid paralysis were registered in Tajikistan since the beginning of this year, According to the Department of Health of the Republic, stressing that "the majority of patients have been cured." According to the ministry, for the past eight years the country registered annually 25-40 cases of the disease. В 2002 году Таджикистан был признан страной свободной от полиомиелита. In 2002, Tajikistan was recognized as a country free from polio. В период с 1997 года до 2002 года в республике не было зарегистрировано случаев этого заболевания. В Минздраве отметили, что в Таджикистан уже прибыли представители Всемирной организации здравоохранения (ВОЗ), которые в настоящее время совместно со специалистами министерства работают над установлением причин роста данного заболевания и предотвращения появления полиомиелита. In the period from 1997 to 2002 in the republic have been reported cases of the disease. Ministry of Health noted that Tajikistan had already arrived from the World Health Organization (WHO), which is currently working with the specialists of the Ministry are working on determining the cause of the growth of this disease and prevent the emergence of polio. ?Министерство здравоохранения обратилось в ВОЗ для установления причин резкого роста этого заболевания?, - сообщает Минздрав. Ожидается, что по рекомендации ВОЗ будет запланирована кампания по иммунизации против полиомиелита, которая будет проведена при поддержке соседних стран. [Комментарий Мод.НП. "The Ministry of Health asked the WHO to establish the reasons for the sharp growth of the disease", - informs the Ministry of Health. It is expected that upon the recommendation of WHO will be scheduled to campaign for polio immunization, which will be held with the support of neighboring countries. [Comment Mod.NP. Последняя крупная вспышка полиомиелита в Таджикистане отмечена в 1991 году. The last major outbreak of poliomyelitis in Tajikistan awarded in 1991. Зарегистрировано 111 случаев заболевания, в том числе 4 случая с летальным исходом. Registered 111 cases, including 4 fatal cases. По происхождению вспышка имела связь с полиовирусами, циркулирующими на Индийском субконтиненте. By origin outbreak had communication with poliovirus circulating in the Indian subcontinent. С 1992 года по 1997 в стране зафиксированы лишь единичные случаи болезни. From 1992 to 1997 the country recorded only isolated cases of the disease. В период с 1997 года до 2002 года полиомиелит в стране не регистрировался, а с 2002 года ежегодно отмечалось 25-50 случаев заболевания. In the period from 1997 to 2002 polio in the country has not registered, and since 2002 the annual observance of 25-50 cases. Рост заболеваемости полиомиелитом, связанный с текущей вспышкой, был отмечен еще в декабря месяца. The increased incidence of polio associated with the current outbreak, there has been more in the month of December. Согласно неофициальному источнику информации подтверждено 7 случаев заболевания, вызванных диким штаммом вируса полиомиелита I типа. According to informal sources of information confirmed 7 cases due to wild strain of polio virus type I. Среди 120 заболевших зарегистрировано 11 летальных исходов, в том числе и 2 ? у взрослых. Among the 120 cases registered 11 deaths, including 2 - adults. Специалисты связывают причины столь масштабной вспышки с дефектами вакцинации. Experts attribute the reason for such large-scale outbreaks with defects vaccination. ? Mod.NP] Смотрите также: 22.04.10 PRO/RUS> Полиомиелит (более 100 случаев) - Таджикистан 20100422.11309 6 - Mod.NP] See also: 22.04.10 PRO / RUS> Poliomyelitis (100 cases) - Tajikistan 20100422.11309 6
 
Re: Tajikistan hit by deadly polio outbreak: WHO

http://www.promedmail.org/pls/otn/f..._BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1000,82397

Archive Number 20100424.1319
Published Date 24-APR-2010
Subject PRO/EDR> Poliomyelitis - Worldwide (04): Tajikistan, Uzbekistan susp


POLIOMYELITIS - WORLDWIDE (04): TAJIKISTAN, UZBEKISTAN SUSPECTED
****************************************************************
A ProMED-mail post
<http://www.promedmail.org>
ProMED-mail is a program of the
International Society for Infectious Diseases
<http://www.isid.org>

In this update:
[1] Report from Tajikistan via ProMED-RUS
[2] WHO confirmation

******
[1] Report from Tajikistan via ProMED-RUS
Date: Fri 23 Apr 2010
From: Nilufar Rakhmanova <promed-rus@promedmail.org> [edited]


[re: Poliomyelitis - Worldwide (03): Tajikistan, RFI 20100423.1314]
-------------------------------------------------------------------
The following information has been sent by our health specialists from
Tajikistan:

"That is true. 120 cases [have been] detected in Khatlon, Dushanbe, and the
[Region] of Republican Subordination. 7 confirmed [cases] with the "wild"
PV1 virus. 11 deaths (including 2 adults). WHO is conducting the
investigation of the outbreak and one CDC representative is also coming for
this reason soon.

There is a WHO plan to vaccinate children under 5 starting from May [2010].

Cases have also been detected in Uzbekistan and Afghanistan."


--
Nilufar Rakhmanova
ProMED-RUS moderator
<promed-rus@promedmail.org>

[Our thanks to our ProMED-RUS colleagues for this rapid confirmation and
additional information. - Mod.MPP]

******
[2] WHO confirmation
Date: Fri 23 Apr 2010
From: Ralph O'Connor <ROConnor@cdc.gov> [edited]


[re: Poliomyelitis - Worldwide (03): Tajikistan, RFI 20100423.1314]
-------------------------------------------------------------------
A WHO team has been sent: see
<http://www.euro.who.int/communicablediseases/outbreaks/20100423_1>

WHO has confirmed this as the 1st wild-type polio outbreak in Tajikistan
since 1997:
Date: Fri 23 Apr 2010
Source: WHO Global Alert and Response (GAR) Disease Outbreak News [edited]
<http://www.who.int/csr/don/2010_04_23/en/index.html>


Polio in Tajikistan, 1st importation since Europe certified polio-free --
23 Apr 2010
----------------------------------------------------------------------
Poliovirus type 1 has been detected in diagnostic samples from cases of
acute flaccid paralysis (AFP) from Tajikistan. This represents the 1st
importation of poliovirus in the WHO European Region since it was certified
polio-free in 2002.

As of 21 Apr 2010, 120 cases of acute flaccid paralysis had been reported
from Tajikistan. The majority of these have onset of paralysis within the
past 2 weeks, prompting the Government to notify WHO of an outbreak. 10 of
the children have died. The vast majority of the cases are children less
than 5 years of age. Preliminary data suggests more than 45 per cent had 4
or more doses of oral polio vaccine [OPV].

To date, poliovirus type 1 has been isolated in diagnostic specimens from 7
of these cases. All cases are in the south west of the country, in an area
bordering Afghanistan and Uzbekistan. Afghanistan is one of the 4 remaining
polio-endemic countries. No cases have been reported in the areas of
Afghanistan bordering Tajikistan.

The Government of Tajikistan has requested technical guidance and support
from WHO. Vaccine for 3 outbreak response rounds is being pre-positioned by
UNICEF Supply Division for Tajikistan.

Tajikistan's last case of clinically confirmed polio was in 1997; the last
case of polio confirmed by virological testing was in 1991. Reported OPV3
[oral polio vaccine] coverage nationwide was 87 per cent in 2008, the last
year for which complete data are available under the WHO/UNICEF joint
reporting process. AFP surveillance indicators in Tajikistan meet
certification standards at the national level. In 2009, Tajikistan reported
35 cases of acute flaccid paralysis, of which none were caused by wild
poliovirus. Globally, more than 90 000 cases of acute flaccid paralysis
were reported in 2009, of which 1606 were caused by wild poliovirus.

A total of 3 cases of acute flaccid paralysis have been reported in
Uzbekistan on the Tajikistan border; poliovirus has not been isolated yet
in laboratory testing. In addition, a child from Tajikistan travelled from
Dushanbe to Tashkent for medical treatment shortly after onset of
paralysis. The Government of Uzbekistan is planning one nationwide round of
vaccination; the Government of Kyrgyzstan, is immunizing children younger
than 5 years of age over the course of European Immunization Week (26-30
Apr 2010).

WHO is communicating with countries in the Region about the outbreak. It is
important that neighboring countries strengthen surveillance for cases of
acute flaccid paralysis, in order to rapidly detect any new poliovirus
importations and facilitate a rapid response. Countries should also analyze
routine immunization coverage data to identify any sub-national gaps in
population immunity to guide catch-up immunization activities and thereby
minimize the consequences of any new virus introduction. Priority should be
given to areas at high-risk of importations and where OPV3/DPT3 coverage is
less than 80 per cent.

This outbreak demonstrates the need to maintain high population immunity
until transmission of polio has been interrupted worldwide.

Public health measures such as enhanced surveillance and immunization may
be put in place at the borders by Tajik health authorities and their
counterparts. It is important that international travellers to and from
polio affected areas are adequately immunized against polio as recommended
in Chapter 6 of International Travel and Health (see link at
<http://www.who.int/ith/ITH2010chapter6.pdf>.

WHO does not recommend the imposition of restrictions to the international
movement of persons as a control measure at this time.

--
Ralph O'Connor
CAPT, USPHS
Health Scientist
Division of Emergency Operations
OPHPR, CDC
USA
<ROConnor@cdc.gov>

[ProMED-mail gratefully acknowledges CAPT O'Connor's contribution.

The close geographic proximity of the outbreak to the border with
Afghanistan and the fact that polio is endemic in that country, do serve as
circumstantial evidence suggestive that the virus may well have originated
in Afghanistan, albeit no poliovirus transmission has been documented in
the border area in Afghanistan. Unfortunately there has also been probable
spread of poliovirus transmission to Uzbekistan with 3 reported suspected
cases. But that being said, we await genetic studies on the virus involved
in this outbreak as well as laboratory confirmation on the suspected cases
in Uzbekistan.

It is curious that this outbreak has apparently been ongoing since December
2009, somewhat beneath the surveillance radarscope. It will be interesting
to see the results of the epidemiologic investigation of the outbreak when
available. From the information given above one can speculate that there
were "sporadic cases" during the period December 2009 through the end of
March 2010, that may well have been missed and attributed to "AFP" in a
country where no polio cases had been seen in 13 years -- until there was
significant increase in AFP cases to flag an outbreak of something unusual.


While there is mention that more than 45 per cent of the cases have a
history of 4 or more doses of OPV, one wonders what the actual vaccine
efficacy is -- when there are higher levels of vaccination coverage, one
expects to find a higher proportion of cases among vaccinated individuals.
One of the many questions to be addressed here is whether this represents a
failure of the vaccine, or a failure to vaccinate (low vaccine efficacy vs
pockets of low vaccination coverage).
 
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