tetano
Editor, Senior Moderator
Syst Biol Reprod Med
. 2024 Dec;70(1):261-271.
doi: 10.1080/19396368.2024.2390514. Epub 2024 Sep 1. Reversible effects of the SARS-CoV-2 on semen parameters
Meritxell Jodar[SUP] 1 2 [/SUP], Yasmina Barral[SUP] 3 [/SUP], Marina Leiva[SUP] 1 [/SUP], Judit Castillo[SUP] 1 [/SUP], Ruth Barrio[SUP] 4 [/SUP], Inés Agustí[SUP] 3 [/SUP], Aina Borràs[SUP] 1 3 [/SUP], Pilar Carrillo[SUP] 3 [/SUP], Roger Matheu[SUP] 1 5 [/SUP], Raquel Ferreti[SUP] 3 [/SUP], Julio Herrero[SUP] 6 [/SUP], Pilar Reimundo[SUP] 7 [/SUP], Jessica Navero-Castillejos[SUP] 8 [/SUP], Gemma Casals[SUP] 3 9 [/SUP], Marta Guimerà[SUP] 1 3 [/SUP], Juan Manuel Corral[SUP] 1 5 [/SUP], Mikel Martinez[SUP] 10 [/SUP], Melchor Carbonell[SUP] 6 [/SUP], Lluís Bassas[SUP] 11 [/SUP], Dolors Manau[SUP] 3 9 [/SUP], Rafael Oliva[SUP] 1 2 [/SUP]
Affiliations
Despite that the SARS-CoV-2 pandemic has been controlled, it has affected a large proportion of the population, raising some concerns about potential sequelae in men at reproductive age. To contribute to the clarification of this issue, we performed a retrospective study comparing semen parameters values before and after confirmed SARS-CoV-2 infection in a large cohort of infertile men, compared to a control group that did not undergo SARS-CoV-2 infection. Wilcoxon test on paired samples and general linear regression model showed that SARS-CoV-2 infection has a detrimental effect on semen volume values (p < 0.005). However, semen volume seems to be significantly lower only during the first spermatogenic cycle after SARS-COV-2 infection (p < 0.005) and mainly in unvaccinated patients (p < 0.05). In addition, we detected alterations in progressive motility in patients infected with the alpha SARS-COV-2 strain (p < 0.05). In conclusion, our results show that although SARS-CoV-2 has a small effect on semen volume and sperm motility in infertile men, depending on the infectious strain or vaccination status, pre-infection values of semen parameters appear to be restored over one spermatogenic cycle after infection.
Keywords: COVID-19; SARS-CoV-2 infection; andrology; male infertility; retrospective study; semen parameters.
. 2024 Dec;70(1):261-271.
doi: 10.1080/19396368.2024.2390514. Epub 2024 Sep 1. Reversible effects of the SARS-CoV-2 on semen parameters
Meritxell Jodar[SUP] 1 2 [/SUP], Yasmina Barral[SUP] 3 [/SUP], Marina Leiva[SUP] 1 [/SUP], Judit Castillo[SUP] 1 [/SUP], Ruth Barrio[SUP] 4 [/SUP], Inés Agustí[SUP] 3 [/SUP], Aina Borràs[SUP] 1 3 [/SUP], Pilar Carrillo[SUP] 3 [/SUP], Roger Matheu[SUP] 1 5 [/SUP], Raquel Ferreti[SUP] 3 [/SUP], Julio Herrero[SUP] 6 [/SUP], Pilar Reimundo[SUP] 7 [/SUP], Jessica Navero-Castillejos[SUP] 8 [/SUP], Gemma Casals[SUP] 3 9 [/SUP], Marta Guimerà[SUP] 1 3 [/SUP], Juan Manuel Corral[SUP] 1 5 [/SUP], Mikel Martinez[SUP] 10 [/SUP], Melchor Carbonell[SUP] 6 [/SUP], Lluís Bassas[SUP] 11 [/SUP], Dolors Manau[SUP] 3 9 [/SUP], Rafael Oliva[SUP] 1 2 [/SUP]
Affiliations
- PMID: 39217625
- DOI: 10.1080/19396368.2024.2390514
Despite that the SARS-CoV-2 pandemic has been controlled, it has affected a large proportion of the population, raising some concerns about potential sequelae in men at reproductive age. To contribute to the clarification of this issue, we performed a retrospective study comparing semen parameters values before and after confirmed SARS-CoV-2 infection in a large cohort of infertile men, compared to a control group that did not undergo SARS-CoV-2 infection. Wilcoxon test on paired samples and general linear regression model showed that SARS-CoV-2 infection has a detrimental effect on semen volume values (p < 0.005). However, semen volume seems to be significantly lower only during the first spermatogenic cycle after SARS-COV-2 infection (p < 0.005) and mainly in unvaccinated patients (p < 0.05). In addition, we detected alterations in progressive motility in patients infected with the alpha SARS-COV-2 strain (p < 0.05). In conclusion, our results show that although SARS-CoV-2 has a small effect on semen volume and sperm motility in infertile men, depending on the infectious strain or vaccination status, pre-infection values of semen parameters appear to be restored over one spermatogenic cycle after infection.
Keywords: COVID-19; SARS-CoV-2 infection; andrology; male infertility; retrospective study; semen parameters.