tetano
Editor, Senior Moderator
Eur J Med Chem. 2011 Apr 8. [Epub ahead of print]
Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases.
Stanley M, Mayr J, Huber W, Vlasak R, Streicher H.
Source
Department of Chemistry and Biochemistry, University of Sussex, Brighton, BN1 9QG, UK.
Abstract
A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.
Copyright ? 2011 Elsevier Masson SAS. All rights reserved.
PMID:
21524502
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21524502
Synthesis and inhibitory activity of sialic acid derivatives targeted at viral sialate-O-acetylesterases.
Stanley M, Mayr J, Huber W, Vlasak R, Streicher H.
Source
Department of Chemistry and Biochemistry, University of Sussex, Brighton, BN1 9QG, UK.
Abstract
A series of sialosides modified at the 4- and 9-hydroxy group were synthesised and tested for inhibition of the viral haemagglutinin-esterase activity from various Orthomyxoviruses and Coronaviruses. While no inhibition of the sialate-4-O-acetylesterases from mouse hepatitis virus strain S or sialodacryoadenitis virus was found, a 9-O-methyl derivative displayed inhibitory activity against recombinant sialate-9-O-acetylesterase from influenza C virus.
Copyright ? 2011 Elsevier Masson SAS. All rights reserved.
PMID:
21524502
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/21524502