tetano
Editor, Senior Moderator
Molecules. 2014 Jan 15;19(1):925-39. doi: 10.3390/molecules19010925.
Synthesis and broad-spectrum antiviral activity of some novel benzo-heterocyclic amine compounds.
Zhang DJ1, Sun WF1, Zhong ZJ1, Gao RM1, Yi H1, Li YH1, Peng ZG2, Li ZR3.
Author information
Abstract
A series of novel unsaturated five-membered benzo-heterocyclic amine derivatives were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities. The biological results showed that most of our synthesized compounds exhibited potent broad-spectrum antiviral activity. Notably, compounds 3f (IC50 = 3.21-5.06 μM) and 3g (IC50 = 0.71-34.87 μM) showed potent activity towards both RNA viruses (influenza A, HCV and Cox B3 virus) and a DNA virus (HBV) at low micromolar concentrations. An SAR study showed that electron-withdrawing substituents located on the aromatic or heteroaromatic ring favored antiviral activity towards RNA viruses.
PMID:
24434668
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24434668
Synthesis and broad-spectrum antiviral activity of some novel benzo-heterocyclic amine compounds.
Zhang DJ1, Sun WF1, Zhong ZJ1, Gao RM1, Yi H1, Li YH1, Peng ZG2, Li ZR3.
Author information
Abstract
A series of novel unsaturated five-membered benzo-heterocyclic amine derivatives were synthesized and assayed to determine their in vitro broad-spectrum antiviral activities. The biological results showed that most of our synthesized compounds exhibited potent broad-spectrum antiviral activity. Notably, compounds 3f (IC50 = 3.21-5.06 μM) and 3g (IC50 = 0.71-34.87 μM) showed potent activity towards both RNA viruses (influenza A, HCV and Cox B3 virus) and a DNA virus (HBV) at low micromolar concentrations. An SAR study showed that electron-withdrawing substituents located on the aromatic or heteroaromatic ring favored antiviral activity towards RNA viruses.
PMID:
24434668
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24434668