tetano
Editor, Senior Moderator
Am J Trop Med Hyg. 2015 Mar 23. pii: 14-0792. [Epub ahead of print]
[h=1]Synergistic Mortality Caused by Plasmodium falciparum During the 1918 Influenza Pandemic.[/h] Shanks GD[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] At the end of the World War I, British medical officers noted that soldiers infected with malaria were more likely to die during the 1918 influenza pandemic than those without malaria. This synergistic mortality appeared to be specific to Plasmodium falciparum and has not been generally noted since 1920. A possible explanation is that a malaria-induced procoagulant state enhanced the activation of influenza virus to increase inflammation and subsequent severe clinical outcomes. Falciparum proteins bind and likely inhibit antithrombin 3 and other factors. Pathogens interact in ways that may inform pathophysiology studies of remote epidemics.
? The American Society of Tropical Medicine and Hygiene.
PMID: 25802427 [PubMed - as supplied by publisher]
[h=1]Synergistic Mortality Caused by Plasmodium falciparum During the 1918 Influenza Pandemic.[/h] Shanks GD[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] At the end of the World War I, British medical officers noted that soldiers infected with malaria were more likely to die during the 1918 influenza pandemic than those without malaria. This synergistic mortality appeared to be specific to Plasmodium falciparum and has not been generally noted since 1920. A possible explanation is that a malaria-induced procoagulant state enhanced the activation of influenza virus to increase inflammation and subsequent severe clinical outcomes. Falciparum proteins bind and likely inhibit antithrombin 3 and other factors. Pathogens interact in ways that may inform pathophysiology studies of remote epidemics.
? The American Society of Tropical Medicine and Hygiene.
PMID: 25802427 [PubMed - as supplied by publisher]