tetano
Editor, Senior Moderator
Emerg Infect Dis. 2011 Mar;17(3):404-11.
Swine influenza virus antibodies in humans, Western europe, 2009.
Gerloff NA, Kremer JR, Charpentier E, Sausy A, Olinger CM, Weicherding P, Schuh J, Van Reeth K, Muller CP.
Centre de Recherche Public de la Sante/Laboratoire National de Sante, Luxembourg, Grand-Duchy of Luxembourg (N.A. Gerloff, J.R. Kremer, E. Charpentier, A. Sausy, C.P. Muller); Laboratoires Reunis, Junglinster, Luxembourg (C.M. Olinger, J. Schuh); Health Directorate, Luxembourg (P. Weicherding); and Ghent University, Ghent, Belgium (K. Van Reeth).
Abstract
Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses-pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a 2007-08 seasonal subtype H1N1-in 211 persons with swine contact and 224 matched controls in Luxembourg. Persons whose profession involved contact with swine had more neutralizing antibodies against SIV and pandemic (H1N1) 2009 virus than did the controls. Controls also had antibodies against these viruses although exposure to them was unlikely. Antibodies against SIV and pandemic (H1N1) 2009 virus correlated with each other but not with seasonal subtype H1N1 virus. Sequential exposure to variants of seasonal influenza (H1N1) viruses may have increased chances for serologic cross-reactivity with antigenically distinct viruses. Further studies are needed to determine the extent to which serologic responses correlate with infection.
PMID: 21392430 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21392430
Swine influenza virus antibodies in humans, Western europe, 2009.
Gerloff NA, Kremer JR, Charpentier E, Sausy A, Olinger CM, Weicherding P, Schuh J, Van Reeth K, Muller CP.
Centre de Recherche Public de la Sante/Laboratoire National de Sante, Luxembourg, Grand-Duchy of Luxembourg (N.A. Gerloff, J.R. Kremer, E. Charpentier, A. Sausy, C.P. Muller); Laboratoires Reunis, Junglinster, Luxembourg (C.M. Olinger, J. Schuh); Health Directorate, Luxembourg (P. Weicherding); and Ghent University, Ghent, Belgium (K. Van Reeth).
Abstract
Serologic studies for swine influenza viruses (SIVs) in humans with occupational exposure to swine have been reported from the Americas but not from Europe. We compared levels of neutralizing antibodies against 3 influenza viruses-pandemic (H1N1) 2009, an avian-like enzootic subtype H1N1 SIV, and a 2007-08 seasonal subtype H1N1-in 211 persons with swine contact and 224 matched controls in Luxembourg. Persons whose profession involved contact with swine had more neutralizing antibodies against SIV and pandemic (H1N1) 2009 virus than did the controls. Controls also had antibodies against these viruses although exposure to them was unlikely. Antibodies against SIV and pandemic (H1N1) 2009 virus correlated with each other but not with seasonal subtype H1N1 virus. Sequential exposure to variants of seasonal influenza (H1N1) viruses may have increased chances for serologic cross-reactivity with antigenically distinct viruses. Further studies are needed to determine the extent to which serologic responses correlate with infection.
PMID: 21392430 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21392430