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Surveillance of Live Poultry Markets for Low Pathogenic Avian Influenza Viruses in Guangxi Province, Southern China, from 2012?2015
Sisi Luo, Zhixun Xie, Zhiqin Xie, Liji Xie, Li Huang, Jiaoling Huang, Xianwen Deng, Tingting Zeng, Sheng Wang, Yanfang Zhang & Jiabo Liu
Scientific Reports 7, Article number: 17577 (2017)
doi:10.1038/s41598-017-17740-0
Download Citation
Influenza virusRisk factors
Received:
26 April 2017
Accepted:
30 November 2017
Published online:
14 December 2017
Abstract
Infections with low pathogenic avian influenza viruses (LPAIVs) can be mild or asymptomatic in poultry; however, in humans, LPAIVs can cause severe infections and death, as demonstrated by the H7N9 and H10N8 human infection outbreaks in 2013 in China. In this study, we conducted an epidemiological survey of LPAIVs at live poultry markets (LPMs) in Guangxi Province, Southern China, which is near several Southeast Asian countries. From January 2012 to December 2015, we collected 3,813 swab samples from poultry at LPMs in Guangxi. Viral isolation, hemagglutination inhibition assay and viral sequencing were utilized to identify LPAIVs in the collected samples. Among the samples, 622 (16.3%) were positive for LPAIVs. Six subtypes (H1, H3, H4, H6, H9 and H11) were individually isolated and identified. Of these subtypes, H3, H6 and H9 were predominant in ducks, geese and chickens, respectively. Among the 622 positive samples, 160 (25.7%) contained more than one subtype, and H8, H10, H12, H13, and H16 were identified among them, which highlights the continuous need for enhanced surveillance of AIVs. These results provide detailed information regarding the epidemic situation of LPAIVs in the area, which can aid efforts to prevent and control AIV transmission in humans and animals.
...
Previously, it was thought that only the H5 and H7 subtypes posed a significant pandemic risk; however, it is now known that strains of other HA subtypes (e.g., H9, H6 and H10) can infect humans and have pandemic potential17. LPAIV surveillance is intrinsically difficult because most LPAIV strains do not cause symptoms or only cause mild symptoms in infected poultry, allowing the viruses to spread silently18. To address this obstacle, intensive surveillance must be conducted if newly emerged reassortant viruses are to be detected early.
...
In conclusion, we investigated the epidemiology of LPAIVs in poultry from LPMs in Guangxi Province, Southern China, an epicenter of avian flu. Our study demonstrates a high prevalence of LPAIVs in poultry in this area and highlights a need to further investigate the genetics and evolution of LPAIVs.
...
https://www.nature.com/articles/s41598-017-17740-0?WT.feed_name=subjects_immunology
Surveillance of Live Poultry Markets for Low Pathogenic Avian Influenza Viruses in Guangxi Province, Southern China, from 2012?2015
Sisi Luo, Zhixun Xie, Zhiqin Xie, Liji Xie, Li Huang, Jiaoling Huang, Xianwen Deng, Tingting Zeng, Sheng Wang, Yanfang Zhang & Jiabo Liu
Scientific Reports 7, Article number: 17577 (2017)
doi:10.1038/s41598-017-17740-0
Download Citation
Influenza virusRisk factors
Received:
26 April 2017
Accepted:
30 November 2017
Published online:
14 December 2017
Abstract
Infections with low pathogenic avian influenza viruses (LPAIVs) can be mild or asymptomatic in poultry; however, in humans, LPAIVs can cause severe infections and death, as demonstrated by the H7N9 and H10N8 human infection outbreaks in 2013 in China. In this study, we conducted an epidemiological survey of LPAIVs at live poultry markets (LPMs) in Guangxi Province, Southern China, which is near several Southeast Asian countries. From January 2012 to December 2015, we collected 3,813 swab samples from poultry at LPMs in Guangxi. Viral isolation, hemagglutination inhibition assay and viral sequencing were utilized to identify LPAIVs in the collected samples. Among the samples, 622 (16.3%) were positive for LPAIVs. Six subtypes (H1, H3, H4, H6, H9 and H11) were individually isolated and identified. Of these subtypes, H3, H6 and H9 were predominant in ducks, geese and chickens, respectively. Among the 622 positive samples, 160 (25.7%) contained more than one subtype, and H8, H10, H12, H13, and H16 were identified among them, which highlights the continuous need for enhanced surveillance of AIVs. These results provide detailed information regarding the epidemic situation of LPAIVs in the area, which can aid efforts to prevent and control AIV transmission in humans and animals.
...
Previously, it was thought that only the H5 and H7 subtypes posed a significant pandemic risk; however, it is now known that strains of other HA subtypes (e.g., H9, H6 and H10) can infect humans and have pandemic potential17. LPAIV surveillance is intrinsically difficult because most LPAIV strains do not cause symptoms or only cause mild symptoms in infected poultry, allowing the viruses to spread silently18. To address this obstacle, intensive surveillance must be conducted if newly emerged reassortant viruses are to be detected early.
...
In conclusion, we investigated the epidemiology of LPAIVs in poultry from LPMs in Guangxi Province, Southern China, an epicenter of avian flu. Our study demonstrates a high prevalence of LPAIVs in poultry in this area and highlights a need to further investigate the genetics and evolution of LPAIVs.
...
https://www.nature.com/articles/s41598-017-17740-0?WT.feed_name=subjects_immunology