tetano
Editor, Senior Moderator
Vaccine. 2014 Jun 19. pii: S0264-410X(14)00694-X. doi: 10.1016/j.vaccine.2014.05.027. [Epub ahead of print]
Summary of knowledge gaps related to quality and efficacy of current influenza vaccines.
Mura M1, Pfleiderer M2, Trouvin JH3, Brasseur D4, Granstrom M5, Shivji R6, Cavaleri M6.
Author information
Abstract
Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Influenza vaccination; Pandemic; Serological criteria; Stakeholders; Vaccine efficacy
PMID:
24954696
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24954696
Summary of knowledge gaps related to quality and efficacy of current influenza vaccines.
Mura M1, Pfleiderer M2, Trouvin JH3, Brasseur D4, Granstrom M5, Shivji R6, Cavaleri M6.
Author information
Abstract
Influenza viruses are a public health threat, as they are pathogenic, highly transmissible and prone to genetic changes. For decades vaccination strategies have been based on trivalent inactivated vaccines, which are regulated by specific guidelines. The progress in scientific knowledge and the lessons learned from the A(H1N1)2009 pandemic have highlighted further the need to improve current guidelines, including the immunogenicity criteria set by the CHMP in 1997, and to promote the discussion on the shortcomings encountered, e.g. the evaluation of vaccine efficacy in the paediatric and elderly populations, the measurement of the naivety of a population, the impact of prior immunity on subsequent vaccinations, and the technical issues with the serological assays for detection of immunity and immunogenicity. The authors attempted to summarise and tackle key gaps in the existing evidence concerning quality and efficacy of influenza vaccines, aiming at favouring a common understanding and a coordinated approach across stakeholders.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Influenza vaccination; Pandemic; Serological criteria; Stakeholders; Vaccine efficacy
PMID:
24954696
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24954696