tetano
Editor, Senior Moderator
J Infect Dis. 2015 Nov 23. pii: jiv563. [Epub ahead of print]
[h=1]Substantial Influenza Vaccine Effectiveness Observed in Households with Children in a Season in which A (pH1N1) Predominated (2013-2014).[/h] Ohmit SE[SUP]1[/SUP], Petrie JG[SUP]1[/SUP], Malosh RE[SUP]1[/SUP], Johnson E[SUP]1[/SUP], Truscon R[SUP]1[/SUP], Aaron B[SUP]1[/SUP], Martens C[SUP]1[/SUP], Cheng C[SUP]1[/SUP], Fry AM[SUP]2[/SUP], Monto AS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We examined influenza vaccine effectiveness (VE) in the 2013-2014 season in which influenza A (pH1N1) predominated. In previous years, in which A (H3N2) predominated, VE was low and negatively affected by prior year vaccination.
[h=4]METHODS:[/h] We enrolled and followed 232 households with 1049 members, including 618 children; specimens were collected from subjects with acute respiratory illnesses. VE in preventing laboratory-confirmed influenza A (pH1N1) was estimated in adjusted models. Pre-season hemagglutination-inhibition and neuraminidase-inhibition antibody titers were determined to assess susceptibility.
[h=4]RESULTS:[/h] Influenza A (pH1N1) was identified in 25 (10.8%) households and 47 (4.5%) individuals. Adjusted VE against infection with influenza A (pH1N1) virus was 66% (95% CI, 23% to 85%), with similar point estimates in children and adults, and against both community and household-acquired infections. VE did not appear different for live-attenuated and inactivated vaccines among children age 2-8 years, although numbers were small. VE was similar for subjects vaccinated in both current and prior seasons and those vaccinated in the current season only; susceptibility titers were consistent with this observation.
[h=4]CONCLUSIONS:[/h] Findings, including substantial significant VE and lack of negative effect of repeated vaccination on VE, were in contrast to those seen in prior seasons where A (H3N2) predominated.
? The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 26597255 [PubMed - as supplied by publisher]
[h=1]Substantial Influenza Vaccine Effectiveness Observed in Households with Children in a Season in which A (pH1N1) Predominated (2013-2014).[/h] Ohmit SE[SUP]1[/SUP], Petrie JG[SUP]1[/SUP], Malosh RE[SUP]1[/SUP], Johnson E[SUP]1[/SUP], Truscon R[SUP]1[/SUP], Aaron B[SUP]1[/SUP], Martens C[SUP]1[/SUP], Cheng C[SUP]1[/SUP], Fry AM[SUP]2[/SUP], Monto AS[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We examined influenza vaccine effectiveness (VE) in the 2013-2014 season in which influenza A (pH1N1) predominated. In previous years, in which A (H3N2) predominated, VE was low and negatively affected by prior year vaccination.
[h=4]METHODS:[/h] We enrolled and followed 232 households with 1049 members, including 618 children; specimens were collected from subjects with acute respiratory illnesses. VE in preventing laboratory-confirmed influenza A (pH1N1) was estimated in adjusted models. Pre-season hemagglutination-inhibition and neuraminidase-inhibition antibody titers were determined to assess susceptibility.
[h=4]RESULTS:[/h] Influenza A (pH1N1) was identified in 25 (10.8%) households and 47 (4.5%) individuals. Adjusted VE against infection with influenza A (pH1N1) virus was 66% (95% CI, 23% to 85%), with similar point estimates in children and adults, and against both community and household-acquired infections. VE did not appear different for live-attenuated and inactivated vaccines among children age 2-8 years, although numbers were small. VE was similar for subjects vaccinated in both current and prior seasons and those vaccinated in the current season only; susceptibility titers were consistent with this observation.
[h=4]CONCLUSIONS:[/h] Findings, including substantial significant VE and lack of negative effect of repeated vaccination on VE, were in contrast to those seen in prior seasons where A (H3N2) predominated.
? The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
PMID: 26597255 [PubMed - as supplied by publisher]