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Substack: A new wave and a new booster? - March 29, 2022

Mary Wilson

Well-known member
2 hr ago
Eric Topol

The inconvenient truth is that we are going to experience a new BA.2 variant wave in the United States—the magnitude of which remains uncertain—and, this highlights the question of whether a 2nd booster (4th shot) would be useful.

In the past month, many countries in Western Europe have been going through a significant 2nd Omicron wave that is attributable to the BA.2 variant, some accompanied by a substantial rise in hospitalizations and deaths. The pattern varies by country, with some like Denmark, Netherlands and Austria having pronounced surges with BA.2 superimposed on BA.1, while others were more discrete. ...

... Why a 2nd Omicron Wave?

Omicron is a family of variants which includes BA.1, BA 1.1, BA.2, and others. Although they share many mutations, BA.2 is quite distinct from BA.1 with 8 unique mutations. Here is the mutation map of these 2 Omicron variants. BA1.l, which was a major part of the US Omicron initial wave, and other countries, only differs from BA.1 by 1 spike mutation (R346K). ...

https://erictopol.substack.com/p/a-new-wave-and-a-new-booster?s=w
 
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