tetano
Editor, Senior Moderator
Bull Exp Biol Med. 2018 Jun 19. doi: 10.1007/s10517-018-4140-8. [Epub ahead of print]
[h=1]Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo.[/h] Kurskaya OG[SUP]1[/SUP], Murashkina TA[SUP]2[/SUP], Alekseev AY[SUP]2[/SUP], Sharshov KA[SUP]2[/SUP], Romakh LP[SUP]2[/SUP], Derko AA[SUP]2[/SUP], Troitskii AV[SUP]2[/SUP], Bystrova TN[SUP]2[/SUP], Shkurupy VA[SUP]2,[/SUP][SUP]3[/SUP], Shestopalov AM[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.
[h=4]KEYWORDS:[/h] antiviral efficiency; influenza virus; oxidized dextran
PMID: 29923002 DOI: 10.1007/s10517-018-4140-8
[h=1]Study of Antiviral Efficiency of Oxidized Dextrans In Vitro and In Vivo.[/h] Kurskaya OG[SUP]1[/SUP], Murashkina TA[SUP]2[/SUP], Alekseev AY[SUP]2[/SUP], Sharshov KA[SUP]2[/SUP], Romakh LP[SUP]2[/SUP], Derko AA[SUP]2[/SUP], Troitskii AV[SUP]2[/SUP], Bystrova TN[SUP]2[/SUP], Shkurupy VA[SUP]2,[/SUP][SUP]3[/SUP], Shestopalov AM[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Antiviral efficiency of oxidized dextrans (OD) with different molecular weights and oxidation degree (OD40min, OD70min, OD40max, and OD70 max) was studied in vitro and in vivo. Dextrans OD40max and OD70max prevented the development of the cytopathic effect of influenza A(H1N1)pdm09 virus in more than 50% MDCK cells vs. control (no OD). Four intranasal doses of OD40min, OD40max, and OD70min and one intranasal dose of OD70max before infection of BALB/c mice with A(H1N1)pdm09 influenza virus significantly reduced mortality and prolonged life span in comparison with controls receiving saline. These and our previous data attest to clear-cut preventive effect of OD in influenza infection.
[h=4]KEYWORDS:[/h] antiviral efficiency; influenza virus; oxidized dextran
PMID: 29923002 DOI: 10.1007/s10517-018-4140-8