sharon sanders
Editor-in-Chief & President
Eurosurveillance, Volume 19, Issue 25, 26 June 2014
Research articles
LIMITED HUMAN-TO-HUMAN TRANSMISSION OF AVIAN INFLUENZA A(H7N9) VIRUS, SHANGHAI, CHINA, MARCH TO APRIL 2013
J Hu1,2, Y Zhu1,2, B Zhao1,2, J Li1, L Liu3, K Gu4, W Zhang5, H Su3, Z Teng1, S Tang1, Z Yuan1, Z Feng6, F Wu ()1
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
These authors contributed equally to this article
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Jin-an District Center for Disease Control and Prevention, Shanghai, China
Huashan Hospital, Fudan University, Shanghai, China
Public Health Emergency Center, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
Citation style for this article: Hu J, Zhu Y, Zhao B, Li J, Liu L, Gu K, Zhang W, Su H, Teng Z, Tang S, Yuan Z, Feng Z, Wu F. Limited human-to-human transmission of avian influenza A(H7N9) virus, Shanghai, China, March to April 2013. Euro Surveill. 2014;19(25)
ii=20838. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20838
Date of submission: 20 January 2014
In April 2013, two members of one family were successively confirmed as cases of avian influenza A(H7N9) virus infection in Shanghai, China. Respiratory specimens from the two cases and their close contacts were tested using real-time reverse-transcription (RT)-PCR. Paired serum specimens from contacts were tested by haemagglutination inhibition assay and microneutralisation test. The index patient developed severe pneumonia. Her husband presented with pneumonia shortly thereafter. Both cases had highly similar clinical features and infection with A(H7N9) virus was confirmed in both cases by genetic analysis. Phylogenetic analysis revealed a high level of similarity between the sequences from the two patients and environmental samples collected from wet markets in Minhang and Changning districts. Six samples from the Changning wet market were confirmed as A(H7N9) positive. Of 27 close contacts, one developed mild respiratory symptoms and another tested positive for A(H7N9) antibodies, but both were negative by real-time RT-PCR. The other 25 close contacts of both cases were A(H7N9) negative.
Limited human-to-human transmission of the virus most likely occurred in the family cluster. However, other close contacts did not test positive for the virus, suggesting limited potential for extensive human-to-human transmission of the virus.
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20838
Research articles
LIMITED HUMAN-TO-HUMAN TRANSMISSION OF AVIAN INFLUENZA A(H7N9) VIRUS, SHANGHAI, CHINA, MARCH TO APRIL 2013
J Hu1,2, Y Zhu1,2, B Zhao1,2, J Li1, L Liu3, K Gu4, W Zhang5, H Su3, Z Teng1, S Tang1, Z Yuan1, Z Feng6, F Wu ()1
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China
These authors contributed equally to this article
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Jin-an District Center for Disease Control and Prevention, Shanghai, China
Huashan Hospital, Fudan University, Shanghai, China
Public Health Emergency Center, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China
Citation style for this article: Hu J, Zhu Y, Zhao B, Li J, Liu L, Gu K, Zhang W, Su H, Teng Z, Tang S, Yuan Z, Feng Z, Wu F. Limited human-to-human transmission of avian influenza A(H7N9) virus, Shanghai, China, March to April 2013. Euro Surveill. 2014;19(25)
ii=20838. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20838Date of submission: 20 January 2014
In April 2013, two members of one family were successively confirmed as cases of avian influenza A(H7N9) virus infection in Shanghai, China. Respiratory specimens from the two cases and their close contacts were tested using real-time reverse-transcription (RT)-PCR. Paired serum specimens from contacts were tested by haemagglutination inhibition assay and microneutralisation test. The index patient developed severe pneumonia. Her husband presented with pneumonia shortly thereafter. Both cases had highly similar clinical features and infection with A(H7N9) virus was confirmed in both cases by genetic analysis. Phylogenetic analysis revealed a high level of similarity between the sequences from the two patients and environmental samples collected from wet markets in Minhang and Changning districts. Six samples from the Changning wet market were confirmed as A(H7N9) positive. Of 27 close contacts, one developed mild respiratory symptoms and another tested positive for A(H7N9) antibodies, but both were negative by real-time RT-PCR. The other 25 close contacts of both cases were A(H7N9) negative.
Limited human-to-human transmission of the virus most likely occurred in the family cluster. However, other close contacts did not test positive for the virus, suggesting limited potential for extensive human-to-human transmission of the virus.
http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20838