Study - Intramuscular Shot produces less inflammatory response than intradermal route

[sharon sanders]

Comparative immunogenicity of trivalent influenza vaccine administered by intradermal or intramuscular route in healthy adults.

<!--AuthorList-->Belshe RB, Newman FK, Wilkins K, Graham IL, Babusis E, Ewell M, Frey SE.
Saint Louis University Medical Center, St. Louis, MO, United States.
The present study was undertaken with controls using equal doses ID and IM plus the standard full dose IM to assess the role of route of vaccine in immunogenicity of inactivated influenza vaccine. The study was a prospective, randomized, active-controlled, open label clinical trial conducted in healthy young adult outpatients to compare the effect of route (IM versus ID) on antibody responses to influenza vaccine. Volunteers received 3, 6 or 9mug of vaccine by ID or IM route; 15mug IM was also studied. Low doses of vaccine given by either route were almost as immunogenic as the standard 15mug IM dose of influenza vaccine. ID route was not superior to IM vaccine at inducing antibodies. ID vaccine induced significantly more local inflammatory response than IM vaccine.
PMID: 17692438 [PubMed - in process]


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[gsgs]

Re: Study - Intramuscular Shot produces less inflammatory response than intradermal r

Re: Study - Intramuscular Shot produces less inflammatory response than intradermal r

> Low doses of vaccine given by either route were almost
> as immunogenic as the standard 15mug IM dose of influenza vaccine

so, we can stretch the standard vaccine ??