Study - Effect of the influenza A (H1N1) live attenuated intranasal vaccine on nitric oxide (FENO) and other volatiles in exhaled breath

[tetano]

TORONTO - Breath tests are commonly used to detect blood alcohol levels and monitor asthma, and now a similar test could possibly help identify people infected with the H1N1 flu virus, a new study suggests.

A breath test measuring the immune response to the H1N1 flu virus could help doctors avoid doling out unnecessary vaccinations to people already infected with the virus, and prioritize those most in need of them, researchers say.

The study was conducted by the Cleveland Clinic in Ohio and New Zealand-based Syft Technologies and published Friday in the Journal of Breath Research.

Study co-author Dr. Raed Dweik said when the H1N1 epidemic happened a couple of years ago physicians were faced with a dilemma related to patient treatment.

"We see these patients coming in with a fever and maybe flu-like symptoms but 'Do they have H1N1 or do they not?'" Dweik, a professor of medicine and director of the pulmonary vascular program at the Cleveland Clinic, said in an interview.

"You need to know quickly and treat them if they have that strain, and if they don't, you probably can treat them differently."

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http://www.winnipegfreepress.com/ar...e-infected-with-flu-virus-study-suggests.html

 

[tetano]

Re: H1N1 breath test could help ID those infected with flu virus, study suggests

Re: H1N1 breath test could help ID those infected with flu virus, study suggests

Effect of the influenza A (H1N1) live attenuated intranasal vaccine on nitric oxide (FENO) and other volatiles in exhaled breath

Journal of Breath Research Volume 5 Number 3 Create an alert RSS this journal

A Mashir et al 2011 J. Breath Res. 5 037107 doi: 10.1088/1752-7155/5/3/037107
Effect of the influenza A (H1N1) live attenuated intranasal vaccine on nitric oxide (FENO) and other volatiles in exhaled breath
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A Mashir1,6, K M Paschke1, D van Duin2, N K Shrestha2, D Laskowski1,3, M K Storer4, B Yen-Lieberman5, S M Gordon2, M Aytekin1 and R A Dweik1,3
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Abstract References

For the 2009 influenza A (H1N1) pandemic, vaccination and infection control were the main modes of prevention. A live attenuated H1N1 vaccine mimics natural infection and works by evoking a host immune response, but currently there are no easy methods to measure such a response. To determine if an immune response could be measured in exhaled breath, exhaled nitric oxide (FENO) and other exhaled breath volatiles using selected ion flow tube mass spectrometry (SIFT-MS) were measured before and daily for seven days after administering the H1N1 2009 monovalent live intranasal vaccine (FluMist?, MedImmune LLC) in nine healthy healthcare workers (age 35 ? 7 years; five females). On day 3 after H1N1 FluMist? administration there were increases in FENO (MEAN?SEM: day 0 15 ? 3 ppb, day 3 19 ? 3 ppb; p < 0.001) and breath isoprene (MEAN?SEM: day 0 59 ? 15 ppb, day 3 99 ? 17 ppb; p = 0.02). MS analysis identified the greatest number of changes in exhaled breath on day 3 with 137 product ion masses that changed from baseline. The exhaled breath changes on day 3 after H1N1 vaccination may reflect the underlying host immune response. However, further work to elucidate the sources of the exhaled breath changes is necessary.


http://iopscience.iop.org/1752-7163/5/3/037107