Studies of Influenza A/H1N1 A/Tomsk/13/2010 Virus Topology during Development of Infectious Process in Mammals

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Bull Exp Biol Med. 2016 Mar 30. [Epub ahead of print]
[h=1]Studies of Influenza A/H1N1 A/Tomsk/13/2010 Virus Topology during Development of Infectious Process in Mammals.[/h] Potapova OV[SUP]1[/SUP], Kovner AV[SUP]2[/SUP], Anikina AG[SUP]1[/SUP], Cherdantseva LA[SUP]1[/SUP], Sharkova TV[SUP]1[/SUP], Shkurupy VA[SUP]1[/SUP], Vasil'eva EV[SUP]1[/SUP], Shestopalov AM[SUP]1[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Influenza A/H1N1 A/Tomsk/13/2010 virus registered in Siberia in 2010 proved to be an extremely pathogenic strain. Dynamic study of the topology of this influenza virus strain in the lungs, liver, kidneys, lymph nodes, and great vessels of infected mice was carried out. Influenza A virus was detected by immunohistochemical methods in cells of different histogenesis in all the studied organs throughout the observation period (days 1-30 postinfection), which indicated effective replication and long persistence of influenza A/H1N1 A/Tomsk/13/2010 virus in mammalian cells.


[h=4]KEYWORDS:[/h] great vessels; influenza A/H1N1 A/Tomsk/13/2010 virus; liver; lungs; lymph nodes

PMID: 27025855 [PubMed - as supplied by publisher]