tetano
Editor, Senior Moderator
EMBO Rep. 2013 Sep 6. doi: 10.1038/embor.2013.130. [Epub ahead of print]
Structure homology and interaction redundancy for discovering virus-host protein interactions.
de Chassey B, Meyniel-Schicklin L, Aublin-Gex A, Navratil V, Chantier T, Andr? P, Lotteau V.
Source
Hospices Civils de Lyon, H?pital de la Croix-Rousse, Laboratoire de virologie, 103 grande rue de la Croix-Rousse, Lyon, F-69004, France.
Abstract
Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.
PMID:
24008843
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24008843
Structure homology and interaction redundancy for discovering virus-host protein interactions.
de Chassey B, Meyniel-Schicklin L, Aublin-Gex A, Navratil V, Chantier T, Andr? P, Lotteau V.
Source
Hospices Civils de Lyon, H?pital de la Croix-Rousse, Laboratoire de virologie, 103 grande rue de la Croix-Rousse, Lyon, F-69004, France.
Abstract
Virus-host interactomes are instrumental to understand global perturbations of cellular functions induced by infection and discover new therapies. The construction of such interactomes is, however, technically challenging and time consuming. Here we describe an original method for the prediction of high-confidence interactions between viral and human proteins through a combination of structure and high-quality interactome data. Validation was performed for the NS1 protein of the influenza virus, which led to the identification of new host factors that control viral replication.
PMID:
24008843
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24008843