tetano
Editor, Senior Moderator
Bull Exp Biol Med. 2012 Jun;153(2):229-32.
Structural and Functional Changes in Pulmonary Macrophages and Lungs of Mice Infected with Influenza Virus A/H5N1 A/goose/Krasnoozerskoye/627/05.
[Article in English, Russian]
Kovner AV, Anikina AG, Potapova OV, Sharkova TV, Cherdanceva LA, Shkurupy VA, Shestopalov AM.
Source
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; State Research Center "Vektor", Novosibirsk oblast, Kol'tsovo, Russia. potapova@soramn.ru.
Abstract
C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination.
PMID:
22816090
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22816090
Structural and Functional Changes in Pulmonary Macrophages and Lungs of Mice Infected with Influenza Virus A/H5N1 A/goose/Krasnoozerskoye/627/05.
[Article in English, Russian]
Kovner AV, Anikina AG, Potapova OV, Sharkova TV, Cherdanceva LA, Shkurupy VA, Shestopalov AM.
Source
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk; State Research Center "Vektor", Novosibirsk oblast, Kol'tsovo, Russia. potapova@soramn.ru.
Abstract
C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination.
PMID:
22816090
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/22816090