tetano
Editor, Senior Moderator
J Pediatr Hematol Oncol. 2018 Apr 26. doi: 10.1097/MPH.0000000000001180. [Epub ahead of print]
[h=1]Steroid Responsive Atypical Hemolytic Uremic Syndrome Triggered by Influenza B Infection.[/h] Mittal N[SUP]1[/SUP], Hartemayer R[SUP]1[/SUP], Jandeska S[SUP]2[/SUP], Giordano L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Atypical hemolytic uremic syndrome (aHUS) is characterized by uncontrolled complement activation leading to thrombotic microangiopathy and severe end-organ damage. The most common trigger for an episode of aHUS in the background of genetic deregulation of the alternative complement pathway is systemic infection. There are only 4 reported cases of aHUS triggered by influenza B thus far. Current accepted therapies for aHUS include plasma exchange and eculizumab. We describe a unique patient with aHUS with a rare membrane cofactor protein mutation triggered by influenza B infection, who achieved complete remission with treatment with high-dose corticosteroids after failure of plasmapheresis.
PMID: 29702545 DOI: 10.1097/MPH.0000000000001180
[h=1]Steroid Responsive Atypical Hemolytic Uremic Syndrome Triggered by Influenza B Infection.[/h] Mittal N[SUP]1[/SUP], Hartemayer R[SUP]1[/SUP], Jandeska S[SUP]2[/SUP], Giordano L[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Atypical hemolytic uremic syndrome (aHUS) is characterized by uncontrolled complement activation leading to thrombotic microangiopathy and severe end-organ damage. The most common trigger for an episode of aHUS in the background of genetic deregulation of the alternative complement pathway is systemic infection. There are only 4 reported cases of aHUS triggered by influenza B thus far. Current accepted therapies for aHUS include plasma exchange and eculizumab. We describe a unique patient with aHUS with a rare membrane cofactor protein mutation triggered by influenza B infection, who achieved complete remission with treatment with high-dose corticosteroids after failure of plasmapheresis.
PMID: 29702545 DOI: 10.1097/MPH.0000000000001180