tetano
Editor, Senior Moderator
Stem Cell Res
. 2021 Jun 20;54:102436.
doi: 10.1016/j.scr.2021.102436. Online ahead of print.
Non-permissive SARS-CoV-2 infection in human neurospheres
Carolina da S G Pedrosa[SUP] 1 [/SUP], Livia Goto-Silva[SUP] 1 [/SUP], Jairo R Temerozo[SUP] 2 [/SUP], Leticia R Q Souza[SUP] 1 [/SUP], Gabriela Vitória[SUP] 1 [/SUP], Isis M Ornelas[SUP] 1 [/SUP], Karina Karmirian[SUP] 3 [/SUP], Mayara A Mendes[SUP] 1 [/SUP], Ismael C Gomes[SUP] 4 [/SUP], Carolina Q Sacramento[SUP] 5 [/SUP], Natalia Fintelman-Rodrigues[SUP] 5 [/SUP], Vinicius Cardoso Soares[SUP] 6 [/SUP], Suelen da Silva Gomes Dias[SUP] 7 [/SUP], José A Salerno[SUP] 3 [/SUP], Teresa Puig-Pijuan[SUP] 8 [/SUP], Julia T Oliveira[SUP] 1 [/SUP], Luiz G H S Aragão[SUP] 1 [/SUP], Thayana C Q Torquato[SUP] 1 [/SUP], Carla Veríssimo[SUP] 4 [/SUP], Diogo Biagi[SUP] 9 [/SUP], Estela M Cruvinel[SUP] 9 [/SUP], Rafael Dariolli[SUP] 10 [/SUP], Daniel R Furtado[SUP] 1 [/SUP], Helena L Borges[SUP] 4 [/SUP], Patrícia T Bozza[SUP] 11 [/SUP], Stevens Rehen[SUP] 12 [/SUP], Thiago Moreno L Souza[SUP] 13 [/SUP], Marília Zaluar P Guimarães[SUP] 14 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.
Keywords: Brain; Neurospheres; New coronavirus; SARS-CoV-2; iPS.
. 2021 Jun 20;54:102436.
doi: 10.1016/j.scr.2021.102436. Online ahead of print.
Non-permissive SARS-CoV-2 infection in human neurospheres
Carolina da S G Pedrosa[SUP] 1 [/SUP], Livia Goto-Silva[SUP] 1 [/SUP], Jairo R Temerozo[SUP] 2 [/SUP], Leticia R Q Souza[SUP] 1 [/SUP], Gabriela Vitória[SUP] 1 [/SUP], Isis M Ornelas[SUP] 1 [/SUP], Karina Karmirian[SUP] 3 [/SUP], Mayara A Mendes[SUP] 1 [/SUP], Ismael C Gomes[SUP] 4 [/SUP], Carolina Q Sacramento[SUP] 5 [/SUP], Natalia Fintelman-Rodrigues[SUP] 5 [/SUP], Vinicius Cardoso Soares[SUP] 6 [/SUP], Suelen da Silva Gomes Dias[SUP] 7 [/SUP], José A Salerno[SUP] 3 [/SUP], Teresa Puig-Pijuan[SUP] 8 [/SUP], Julia T Oliveira[SUP] 1 [/SUP], Luiz G H S Aragão[SUP] 1 [/SUP], Thayana C Q Torquato[SUP] 1 [/SUP], Carla Veríssimo[SUP] 4 [/SUP], Diogo Biagi[SUP] 9 [/SUP], Estela M Cruvinel[SUP] 9 [/SUP], Rafael Dariolli[SUP] 10 [/SUP], Daniel R Furtado[SUP] 1 [/SUP], Helena L Borges[SUP] 4 [/SUP], Patrícia T Bozza[SUP] 11 [/SUP], Stevens Rehen[SUP] 12 [/SUP], Thiago Moreno L Souza[SUP] 13 [/SUP], Marília Zaluar P Guimarães[SUP] 14 [/SUP]
Affiliations
- PMID: 34186311
- PMCID: PMC8236004
- DOI: 10.1016/j.scr.2021.102436
Abstract
Coronavirus disease 2019 (COVID-19) was initially described as a viral infection of the respiratory tract. It is now known, however, that several other organs are affected, including the brain. Neurological manifestations such as stroke, encephalitis, and psychiatric conditions have been reported in COVID-19 patients, but the neurotropic potential of the virus is still debated. Herein, we sought to investigate SARS-CoV-2 infection in human neural cells. We demonstrated that SARS-CoV-2 infection of neural tissue is non-permissive, however, it can elicit inflammatory response and cell damage. These findings add to the hypothesis that most of the neural damage caused by SARS-CoV-2 infection is due to a systemic inflammation leading to indirect harmful effects on the central nervous system despite the absence of local viral replication.
Keywords: Brain; Neurospheres; New coronavirus; SARS-CoV-2; iPS.